Fluoxetine Impurity 18 CAS 60577-28-8
| CAS No. | 60577-28-8 |
| Molecular Formula | C11H17NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Fluoxetine Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Fluoxetine Impurity 18 (CAS 60577-28-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H17NOHCl and a molecular weight of 215.72 g/mol.
The molecular framework of Fluoxetine Impurity 18 (C11H17NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H17NO HCl |
| Molecular Weight | 215.72 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Fluoxetine Standards
- Fluoxetine Impurity 37 (CAS 101-98-4)
- Fluoxetine Impurity 44 (CAS 101-98-4（free base）)
- Fluoxetine Impurity 19 (CAS 1026723-45-4)
- Fluoxetine Impurity 26 (CAS 103756-12-3)
- (S)-Fluoxetine Hydrochloride (CAS 114247-06-2)
- (R)-Fluoxetine Hydrochloride (CAS 114247-09-5)
- Fluoxetine oxalate, >98% (CAS 114414-02-7)
- Fluoxetine-d5 HCl (CAS 1173020-43-3)
Recommended Standards
- Ornidazole Impurity 51 (CAS CATO-C4X-133151)
- Bumetanide Impurity 20 (CAS CATO-C4X-198620)
- Brivaracetam impurity 94 (CAS 2052297-76-2)
- Chlorophosphine C.I. No. 19555 (CAS 14500-83-5)
- Ethyl DL-3-isothiocyanatobutyrate (CAS 206750-29-0)
- 2-ethyl-4-fluorobenZoic acid (CAS 194487-61-1)
- 2-Bromo-4-(difluoromethyl)-6-methylnicotinaldehyde (CAS 1806913-74-5)
- 2-Iodo-N,3-dimethylbenzamide (CAS 887234-45-9)
- 2,6-Dichloro-3-(hydroxymethyl)pyridine (CAS 55304-90-0)
- Human glucagon CRS (CAS 9007-92-5)
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