3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one CAS 606491-81-0
| CAS No. | 606491-81-0 |
| Molecular Formula | C7H8F2O3 |
| Molecular Weight | 178.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (CAS 606491-81-0) is a high-purity analytical reference standard with the molecular formula C7H8F2O3 and a molecular weight of 178.13 g/mol.
The molecular framework of 3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (C7H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8F2O3 |
| Molecular Weight | 178.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
Related Difluoroacetyl Standards
- (+)-3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (CAS 183279-72-3)
- 2-(2,2-Difluoroacetyl)cyclohexanone (CAS 149894-28-0)
- 4-(2,2-Difluoroacetyl)benzonitrile (CAS 1176519-89-3)
- 2-(2,2-difluoroacetyl)bicyclo[3.1.0]hexan-3-one (CAS 1626337-81-2)
- N-(2,2-Difluoroacetyl)-2,2-difluoroacetohydrazide (CAS 155093-22-4)
- 3-(2,2-Difluoroacetyl)bicyclo[4.1.0]heptan-2-one (CAS 1956335-29-7)
- 2-(2,2-Difluoroacetyl)cyclohexane-1,3-dione (CAS 1342797-24-3)
- 2-(2,2-Difluoroacetyl)cyclopentan-1-one (CAS 938001-14-0)
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