3-(2-Chlorophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one CAS 60931-28-4
| CAS No. | 60931-28-4 |
| Molecular Formula | C9H7ClN2O3 |
| Molecular Weight | 226.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(2-Chlorophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one (CAS 60931-28-4), molecular formula C9H7ClN2O3 and molecular weight 226.62 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 3-(2-Chlorophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClN2O3 |
| Molecular Weight | 226.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 2-Chloro-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide (CAS 496056-68-9)
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- 2-(6-Chloro-2-oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acid (CAS 653599-21-4)
- 3',5-Dimethyl-[3,5'-biisoxazole]-4'-carbonyl chloride (CAS 306936-71-0)
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- 1-Methyl-N-(2-methylcyclopentyl)-1h-pyrazol-3-amine (CAS 1490858-65-5)
- N-(1-(2-((2,6-Diethylphenyl)amino)-2-oxoethyl)-piperidin-4-yl)-3-fluorobenzamide (CAS 836679-42-6)
- 3-Iodo-5-isopropyl-1H-pyrazolo[4,3-b]pyridine (CAS 2060590-93-2)
- 3-(1H-pyrazol-5-yl)pyrrolidin-3-ol (CAS 1396999-92-0)
- 3,5-Dichloro-2-(piperidin-4-yl)pyridine (CAS 1260895-53-1)
- 2,7-Diamino-4-(3-(benzyloxy)phenyl)-4h-chromene-3-carbonitrile (CAS 355411-88-0)
- 5-Bromo-6-methyl-N-phenylpyrimidin-4-amine (CAS 61766-78-7)
- (S)-3-((2,5-Dichlorobenzyl)oxy)pyrrolidine hydrochloride (CAS 1289585-41-6)
- Biotinyl-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802086-28-7)
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