4-Amino-5-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol CAS 61019-25-8
| CAS No. | 61019-25-8 |
| Molecular Formula | C8H7FN4S |
| Molecular Weight | 210.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Amino-5-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol (CAS 61019-25-8), a certified reference material (molecular formula C8H7FN4S, MW 210.23 g/mol) for analytical method development and quality control.
The molecular framework of 4-Amino-5-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol (C8H7FN4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 4-Amino-5-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7FN4S |
| Molecular Weight | 210.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- N-Benzyl-5-fluoro-2-nitroaniline (CAS 131885-34-2)
- Ethyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate (CAS 1951441-84-1)
- 2-(Piperazin-1-yl)-2-(pyridin-3-yl)acetonitrile (CAS 137075-14-0)
- 2-Oxo-2-(3-oxopyrazolidin-1-yl)ethyl morpholine-4-carbodithioate (CAS 338394-08-4)
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- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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