5-(2,5-Dimethoxybenzylidene)-2-(4-ethoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one CAS 617694-41-4
| CAS No. | 617694-41-4 |
| Molecular Formula | C21H19N3O4S |
| Molecular Weight | 409.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(2,5-Dimethoxybenzylidene)-2-(4-ethoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 617694-41-4), molecular formula C21H19N3O4S and molecular weight 409.46 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(2,5-Dimethoxybenzylidene)-2-(4-ethoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (C21H19N3O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19N3O4S |
| Molecular Weight | 409.46 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dimethoxybenzylidene Standards
- 5-(3,4-Dimethoxybenzylidene)-2-(4-ethoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 538340-02-2)
- 4-(3,4-Dimethoxybenzylidene)-1-(2-methoxy-4-nitrophenyl)-2-methyl-1H-imidazol-5(4H)-one (CAS 78311-94-1)
- 3,4-Bis(3,4-dimethoxybenzylidene)dihydrofuran-2,5-dione (CAS 63339-53-7)
- 5-(2,4-Dimethoxybenzylidene)-2-(4-isopropoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 618073-57-7)
- N'-(2,5-Dimethoxybenzylidene)-3-(3-nitrophenyl)-1H-pyrazole-5-carbohydrazide (CAS 302918-32-7)
- 2-(2,3-Dimethoxybenzylidene)-6-phenyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione (CAS 463366-94-1)
- 2-(2,5-Dimethoxybenzylidene)-6-phenyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione (CAS 307506-42-9)
- 4-(2,3-Dimethoxybenzylidene)-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 721425-05-4)
Recommended Standards
- 3-[(1S,2S)-2-(Hydroxymethyl)-1H,2H,3H-naphtho[2,1-b]pyran-1-yl]-1-(4-nitrophenyl)thiourea (CAS 318959-03-4)
- 3-(4-Methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole (CAS 865565-29-3)
- 5-(4-Hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-N-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide (CAS 444146-92-3)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide (CAS 573970-62-4)
- 5-Iodo-6-methoxypicolinic acid (CAS 1823343-86-7)
- 1-(2-(2-Ethoxyethoxy)ethoxy)butane (CAS 3895-17-8)
- (R)-3-((2-hydroxybutyl)amino)thietane 1,1-dioxide (CAS 1846752-19-9)
- 2-Methyl-4-phenyl-1H-imidazole-1-carbonitrile (CAS 83505-78-6)
- 5-bromo-6-fluoro-3-methyl-1H-indazole (CAS 864773-66-0)
- N-(5-Nitropyrimidin-2-yl)cyclohexanecarboxamide (CAS 331808-66-3)
- 4-Chloro-3-(difluoromethyl)-5-(trifluoromethyl)picolinonitrile (CAS 1805361-18-5)
- 2-((3-Chlorobenzyl)oxy)benzaldehyde (CAS 40359-59-9)
- 5-Hydroxyhexanoic acid (CAS 44843-89-2)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
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