1-(O-tolyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide CAS 618091-00-2
| CAS No. | 618091-00-2 |
| Molecular Formula | C12H11F3N4O |
| Molecular Weight | 284.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(O-tolyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (CAS 618091-00-2) is a high-purity analytical reference standard with the molecular formula C12H11F3N4O and a molecular weight of 284.24 g/mol.
The molecular framework of 1-(O-tolyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (C12H11F3N4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11F3N4O |
| Molecular Weight | 284.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related O Standards
- 1-(P-tolyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (CAS 618090-91-8)
- 2-(4-(3-(O-tolyl)ureido)phenyl)acetic acid (CAS 181517-99-7)
- 2-((4-(M-tolyl)piperazin-1-yl)sulfonyl)ethan-1-amine (CAS 951919-75-8)
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Recommended Standards
- (4Z)-1-Methyl-4-({[(pyridin-3-yl)methyl]amino}methylidene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 320425-18-1)
- (4E)-4-[2-(4-Fluorophenyl)hydrazin-1-ylidene]-3,4-dihydro-1H-2-benzopyran-1,3-dione (CAS 339021-15-7)
- 1,3,2-Dioxaborolane, 2-hydroxy-4-tetradecyl- (CAS 84819-41-0)
- (2R,3R,4S,5R)-2-(4-amino-6-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 405231-00-7)
- (Z)-2-(4-Hydroxybenzylidene)benzofuran-3(2H)-one (CAS 112980-31-1)
- tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate (CAS 1363380-79-3)
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