3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1h-pyrazole-5-carboxylic acid CAS 618102-59-3
| CAS No. | 618102-59-3 |
| Molecular Formula | C16H9ClF2N2O2 |
| Molecular Weight | 334.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1h-pyrazole-5-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1h-pyrazole-5-carboxylic acid (CAS 618102-59-3), a certified reference material (molecular formula C16H9ClF2N2O2, MW 334.70 g/mol) for analytical method development and quality control.
The molecular framework of 3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1h-pyrazole-5-carboxylic acid (C16H9ClF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H9ClF2N2O2 |
| Molecular Weight | 334.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)nicotinic acid (CAS 303149-99-7)
- Methyl 4-chloro-2,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (CAS 104022-83-5)
- 1-(3-Chloro-4-fluorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618102-76-4)
- 5-Chloro-3-(2-methoxy-5-nitrobenzyl)benzo[d]oxazol-2(3H)-one (CAS 898796-77-5)
- 2-Chloro-5-(trifluoromethyl)phenylboronic acid pinacol ester (CAS 1146214-95-0)
- n1-Phenylpiperidine-1,4-dicarboxamide (CAS 401589-80-8)
- 3-Pyridinecarboxamide, 1,2-dihydro-N-methoxy-N-methyl-2-oxo- (CAS 1198166-08-3)
- N-(1-Cyanocyclohexyl)benzamide (CAS 92255-24-8)
- N-(5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide (CAS 851094-50-3)
- 5-Bromo-3-(chloromethyl)-2-methylpyridine (CAS 1211540-73-6)
- Methanediol, 1-(1-oxido-3-pyridinyl)-, 1,1-diacetate (CAS 114951-35-8)
- 4-Chloro-2,6-dimethoxy-1,5-naphthyridine (CAS 959990-37-5)
- 2-((2-Chlorothiazol-5-yl)methyl)isoindoline-1,3-dione (CAS 120740-09-2)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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