4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one CAS 618369-75-8
| CAS No. | 618369-75-8 |
| Molecular Formula | C22H13ClN2O4S |
| Molecular Weight | 436.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one (CAS 618369-75-8), molecular formula C22H13ClN2O4S and molecular weight 436.87 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one (C22H13ClN2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C22H13ClN2O4S |
| Molecular Weight | 436.87 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Benzofuran Standards
- 4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1,5-dihydro-2H-pyrrol-2-one (CAS 618877-26-2)
- N-(4-(Benzofuran-2-yl)-6-methylbenzo[d]thiazol-2-yl)-2-(2,3-dihydrobenzofuran-5-yl)acetamide (CAS 2288708-59-6)
- (S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one (CAS 1332331-08-4)
- 1-(Benzofuran-2-yl)-2-(triphenylphosphoranylidene)ethanone (CAS 23489-30-7)
- N-((1-(Benzofuran-2-carbonyl)piperidin-4-yl)methyl)benzo[d]thiazole-2-carboxamide (CAS 1235315-51-1)
- 3-(Benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)propan-1-one (CAS 209746-56-5)
- (S)-(3-((2-(4-(Benzofuran-5-yl)phenyl)-1H-imidazo[4,5-c]pyridin-1-yl)methyl)pyrrolidin-1-yl)(cyclopropyl)methanone (CAS 1309805-49-9)
- N-(5-(benzofuran-2-yl)-1,3,4-oxadiazol-2-yl)-4-((4-methylpiperidin-1-yl)sulfonyl)benzamide (CAS 922044-21-1)
Recommended Standards
- (2Z)-2-(2H-1,3-Benzodioxol-5-yl)-3-{4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}prop-2-enenitrile (CAS 866019-60-5)
- Ertugliflozin (CAS 1210344-57-2)
- 1-(3-Chloro-4-fluorophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796900-09-8)
- 3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-thiobenzoic acid S-(4-chloro-phenyl) ester (CAS 1311279-00-1)
- Methyl 2-(2-chloroacetamido)-4-(4-chlorophenyl)thiophene-3-carboxylate (CAS 519016-64-9)
- N-[4-(4-Pentylcyclohexyl)phenyl]naphthalene-2-sulfonamide (CAS 478041-36-0)
- (5-Fluoro-2H-indazol-3-yl)methanol (CAS 518990-02-8)
- Spiro[indene-1,4'-piperidine] hydrochloride, 97% (CAS 137730-67-7)
- D-Homocysteine (CAS 6027-14-1)
- 4-(Methylsulfonyl)benzimidamide (CAS 17574-50-4)
- 2-(2-(Chloromethyl)-2-methylbutyl)thiophene (CAS 1498450-62-6)
- 2-Fluoro-4-isothiocyanatopyridine (CAS 1301254-81-8)
- 1-(3-Aminopiperidin-1-yl)-2,2,2-trifluoroethan-1-one (CAS 1260832-30-1)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com