3-(2,4-Dichloro-5-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid CAS 618382-93-7
| CAS No. | 618382-93-7 |
| Molecular Formula | C16H8Cl2F2N2O2 |
| Molecular Weight | 369.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(2,4-Dichloro-5-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(2,4-Dichloro-5-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618382-93-7), molecular formula C16H8Cl2F2N2O2 and molecular weight 369.15 g/mol, is a CATO reference standard with documented purity and traceability.
3-(2,4-Dichloro-5-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (C16H8Cl2F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8Cl2F2N2O2 |
| Molecular Weight | 369.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- Ethyl 3-(2,6-dichloro-4-(trifluoromethyl)phenoxy)-1H-pyrazole-5-carboxylate (CAS 1338333-95-1)
- 3',6'-Dichloro-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (CAS 630-88-6)
- (E)-2,4-dichloro-N'-(4-(3-fluoropropoxy)benzylidene)benzohydrazide (CAS 477862-45-6)
- 2,4-Dichloro-N-(3-cyano-4-(methylsulfonyl)phenyl)benzamide (CAS 320421-55-4)
- 2,5-Dichloro-N-(3-cyano-4-(methylsulfonyl)phenyl)benzamide (CAS 320421-60-1)
- 2-((5-((4,5-Dichloro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-yl)thio)-1-phenylethanone (CAS 650592-53-3)
- 5-(6,7-Dichloro-2,3-dihydro-1,4-benzodioxin-5-yl)-2-(methylsulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 861210-32-4)
- 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide (CAS 1346233-68-8)
Recommended Standards
- 2-(4-Bromophenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (CAS 821807-60-7)
- 3-(2,4-Dichlorophenyl)-1-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618383-10-1)
- (4-Bromo-2,5-dihexylphenyl)boronic acid (CAS 122465-86-5)
- rel-(2R,5R)-5-(5-Bromo-2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine (CAS 2641065-10-1)
- Furan-2,5-dicarbohydrazide (CAS 26095-97-6)
- N-(4,6-Diphenylpyrimidin-2-yl)cyclobutanecarboxamide (CAS 820961-73-7)
- 4-chloropyrimido[4,5-d][1,3]diazine (CAS 1197193-18-2)
- 3-Bromo-2-methylquinoline (CAS 343330-62-1)
- 3-(Tetrahydrofuran-3-yl)-2h-indazole hydrochloride (CAS 2197053-96-4)
- Benzene, 1-bromo-3-chloro-2-[[(4-methoxyphenyl)methoxy]methyl]- (CAS 1980784-00-6)
- 2,4-Dichloro-5-(difluoromethyl)pyridine (CAS 1256833-30-3)
- Methyl 4-methyl-3-oxopent-4-enoate (CAS 37734-09-1)
- 3-[(2,4,6-trifluorophenyl)carbonyl]pyridine (CAS 1094348-00-1)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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