Lenvatinib Impurity 70 CAS 619-16-9
| CAS No. | 619-16-9 |
| Molecular Formula | C6H3ClN2O4 |
| Molecular Weight | 202.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lenvatinib Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lenvatinib Impurity 70 (CAS 619-16-9, C6H3ClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lenvatinib Impurity 70 (C6H3ClN2O4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 202.55 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN2O4 |
| Molecular Weight | 202.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 128 (CAS CATO-C4X-1140128)
- Lenvatinib Impurity 110 (CAS CATO-C4X-1140110)
- Lenvatinib Impurity 104 (CAS CATO-C4X-1140104)
- Lenvatinib Impurity 93 (CAS 1378260-39-9)
- Lenvatinib Impurity 75 (CAS CATO-C4X-114075)
- Lenvatinib Impurity 174 (CAS CATO-C4X-1140174)
- Lenvatinib Impurity 114 (CAS 42832-22-4)
- Lenvatinib Impurity 115 (CAS 106868-33-1)
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