Procaine Impurity 3 CAS 619-19-2
| CAS No. | 619-19-2 |
| Molecular Formula | C7H5NO5 |
| Molecular Weight | 183.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Procaine Impurity 3 (C7H5NO5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Procaine Impurity 3 (CAS 619-19-2, C7H5NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5NO5 |
| Molecular Weight | 183.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Procaine Standards
Recommended Standards
- 2,3-Dinitroaniline (CAS 602-03-9)
- Darolutamide Impurity 32 (CAS CATO-C4X-310632)
- 2,5-Dinitroaniline (CAS 619-18-1)
- 2,6-Dinitroaniline (CAS 606-22-4)
- Ozenoxacin Impurity 65 (CAS CATO-C4X-279665)
- Propafenone EP Impurity E (CAS 165279-79-8)
- Piracetam Impurity N5 (CAS 2454698-45-2)
- 3-Acetyl-5-bromopyridin-2(1H)-one (CAS 1260775-35-6)
- (R)-4-(tert-Butoxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid (CAS 155542-33-9)
- 4-((Sec-butylamino)methyl)benzonitrile (CAS 1019500-68-5)
- Methyl 4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate (CAS 606976-41-4)
- 3-Acetyl-1,2,5,8-tetrahydroxyanthracene-9,10-dione (CAS 92468-57-0)
- 1-(3-Amino-4-(benzyloxy)phenyl)ethanone (CAS 14347-15-0)
- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
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