Norepinephrine Impurity 66 HCl CAS 62-22-6
| CAS No. | 62-22-6 |
| Molecular Formula | C10H15NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Norepinephrine Impurity 66 HCl.
As a process- or degradation-related impurity, Norepinephrine Impurity 66 HCl (CAS 62-22-6, C10H15NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Norepinephrine Impurity 66 HCl (C10H15NO3HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Norepinephrine Impurity 66 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H15NO3 HCl |
| Molecular Weight | 233.69 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Norepinephrine Standards
- Norepinephrine Impurity 50 (CAS 100622-09-1)
- Norepinephrine Impurity 103 (CAS 102743-86-2)
- Norepinephrine EP Impurity F (CAS 103-49-1)
- Norepinephrine Impurity 107 (CAS 112346-92-6)
- Norepinephrine Impurity 28 (CAS 117883-03-1)
- Norepinephrine Impurity 22 (CAS 1197-09-7)
- Norepinephrine Impurity 36 (CAS 121-28-8)
- Norepinephrine Impurity 161 (CAS 1215-29-8（free acid）)
Recommended Standards
- Ziprasidone Impurity 30 (CAS 188797-80-0)
- Chlorphenamine Impurity 65 DiHCI (CAS CATO-C4X-118865)
- Ciclopirox EP Impurity C (CAS 67587-24-0)
- 4-((3-Allyl-2-hydroxybenzylidene)amino)-3-(2-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-30-7)
- Big Endothelin-1 (1-39), porcine (CAS 124834-83-9)
- n-(4-Chlorobenzyl)pentan-3-amine (CAS 108157-25-1)
- Oregon-BAPTA Green 1AM (CAS 244167-57-5)
- Lifitegrast Impurity 76 (CAS CATO-C4X-240976)
- 2-[1-Cyano-2-(dimethylamino)vinyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (CAS 338977-21-2)
- Semaglutide (CAS 910463-68-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com