6-Chloro-2-methylbenzo[d]isothiazol-3(2h)-one 1,1-dioxide CAS 6202-68-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloro-2-methylbenzo[d]isothiazol-3(2h)-one 1,1-dioxide.

6-Chloro-2-methylbenzo[d]isothiazol-3(2h)-one 1,1-dioxide (CAS 6202-68-2) is a high-purity analytical reference standard with the molecular formula C8H6ClNO3S and a molecular weight of 231.66 g/mol.

6-Chloro-2-methylbenzo[d]isothiazol-3(2h)-one 1,1-dioxide (C8H6ClNO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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