2,2,3,3-Tetrafluoro-1,4-benzodioxine-6-boronic acid CAS 622383-86-2
| CAS No. | 622383-86-2 |
| Molecular Formula | C8H5BF4O4 |
| Molecular Weight | 251.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,2,3,3-Tetrafluoro-1,4-benzodioxine-6-boronic acid.
CATO supplies 2,2,3,3-Tetrafluoro-1,4-benzodioxine-6-boronic acid (CAS 622383-86-2), a certified reference material (molecular formula C8H5BF4O4, MW 251.93 g/mol) for analytical method development and quality control.
Structurally, 2,2,3,3-Tetrafluoro-1,4-benzodioxine-6-boronic acid (C8H5BF4O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.5, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 251.93 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5BF4O4 |
| Molecular Weight | 251.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
Related Tetrafluoro Standards
- (2,2,4,4-Tetrafluoro-4H-benzo[d][1,3]dioxin-6-yl)boronic acid (CAS 870822-77-8)
- (2,3,5,6-Tetrafluoro-4-isopropoxyphenyl)boronic acid (CAS 871126-28-2)
- (2,3,5,6-Tetrafluoro-4-propoxyphenyl)boronic acid (CAS 871125-71-2)
- 2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (CAS 180091-38-7)
- 2,2,3,3-Tetrafluoro-1,4-benzodioxane-5- carboxylic acid (CAS 398156-39-3)
- (2,3,5,6-Tetrafluoro-phenoxy)-acetic acid ethyl ester (CAS 14742-38-2)
- Methyl 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzoate (CAS 62172-91-2)
- 1,1,1,2-Tetrafluoro-2-(trifluoromethyl)oct-3-ene (CAS 261760-26-3)
Recommended Standards
- 2-(2-Bromoethenyl)-1,3-dichlorobenzene (CAS 430434-58-5)
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- Methyl 4-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate (CAS 114698-43-0)
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- Ethyl 2-amino-4-(2,3-dichlorophenyl)thiophene-3-carboxylate (CAS 1101067-95-1)
- Azelastine Impurity 29 (CAS 174826-63-2)
- 3-Iodo-2-methyl-5-nitropyridine (CAS 911434-20-3)
- 6-Chloro-3,3,7-trimethyl-2H-oxazolo[3,2-a]pyrimidin-5(3H)-one (CAS 34112-90-8)
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- (3-Bromo-4-methylphenyl)(thiophen-2-yl)methanone (CAS 81140-51-4)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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