2,2-difluoro-2-(thiophen-2-yl)acetic acid CAS 622847-29-4
| CAS No. | 622847-29-4 |
| Molecular Formula | C6H8F2O2S |
| Molecular Weight | 182.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,2-difluoro-2-(thiophen-2-yl)acetic acid.
CATO supplies 2,2-difluoro-2-(thiophen-2-yl)acetic acid (CAS 622847-29-4), a certified reference material (molecular formula C6H8F2O2S, MW 182.19 g/mol) for analytical method development and quality control.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 2,2-difluoro-2-(thiophen-2-yl)acetic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 182.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2,2-difluoro-2-(thiophen-2-yl)acetic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O2S |
| Molecular Weight | 182.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
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