3,5-Difluorobiphenyl CAS 62351-48-8
| CAS No. | 62351-48-8 |
| Molecular Formula | C12H8F2 |
| Molecular Weight | 190.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3,5-Difluorobiphenyl is closely related to fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3,5-Difluorobiphenyl (CAS 62351-48-8), molecular formula C12H8F2 and molecular weight 190.19 g/mol, is a CATO reference standard with documented purity and traceability.
3,5-Difluorobiphenyl (C12H8F2) contains fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8F2 |
| Molecular Weight | 190.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F-containing |
Related Difluorobiphenyl Standards
- 2,3-Difluorobiphenyl (CAS 67277-32-1)
- 4,4′-Difluorobiphenyl (CAS 398-23-2)
- 2,2'-Difluorobiphenyl (PFB 4) 2000 microg/mL in Methyl-tert-butyl ether 1-fluoro-2-(2-fluorophenyl)benzene 2,2'-Difluorobiphenyl 388-82-9 (CAS 388-82-9)
- 2,4-Difluorobiphenyl-3-amine (CAS 1214381-88-0)
- 3',3-Difluorobiphenyl-2-carbaldehyde (CAS 1214354-89-8)
- 3',6-Difluorobiphenyl-2-carbaldehyde (CAS 1214390-07-4)
- (3',2-Difluorobiphenyl-4-yl)methanamine (CAS 1214336-07-8)
- (4',4-Difluorobiphenyl-3-yl)methanol (CAS 1214359-16-6)
Recommended Standards
- 3,4-Difluoro-1,1'-biphenyl (CAS 67277-33-2)
- 3-4-O-Isopropylidene-L-arabinose (CAS 40031-36-5)
- 3,3'-Difluoro-1,1'-biphenyl (CAS 396-64-5)
- 3-4-O-Isopropylidene-β-D-arabinopyranose (CAS 58645-40-2)
- (S)-2-acetamido-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-3-phenylpropanamide (CAS 19361-52-5)
- 1-(3-Methoxybenzyl)-3,5-dimethyl-1h-pyrazol-4-amine (CAS 1001519-29-4)
- tert-Butyl 4-((3-cyanopyridin-2-yl)oxy)piperidine-1-carboxylate (CAS 1065484-09-4)
- Valaciclovir EP Impurity K (CAS CATO-C4X-124811)
- 1,5-Bis((4-methoxyphenyl)amino)anthracene-9,10-dione (CAS 2944-16-3)
- Vonoprazan Impurity 205 (CAS CATO-C4X-1020205)
- 1-[(4S)-4-Phenyl-2-thioxo-3-thiazolidinyl]ethanone (CAS 1519060-84-4)
- tert-Butyl (3aR,9bR)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carboxylate (CAS 1932055-54-3)
- N-(3-chlorophenyl)-2-((5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)propanamide (CAS 332161-81-6)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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