(3-Amino-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone CAS 625377-74-4
| CAS No. | 625377-74-4 |
| Molecular Formula | C22H14F3N3O3S |
| Molecular Weight | 457.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(3-Amino-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone (CAS 625377-74-4) is a high-purity analytical reference standard with the molecular formula C22H14F3N3O3S and a molecular weight of 457.43 g/mol.
(3-Amino-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone (C22H14F3N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C22H14F3N3O3S |
| Molecular Weight | 457.43 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
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- 3-Amino-6-benzyl-N-(2-methoxyphenyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 723748-37-6)
- Amino-PEG10-alcohol (CAS 129449-09-8)
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- 2-Amino-4-(4-chlorophenyl)-7,7-dimethyl-3-(4-methylbenzenesulfonyl)-5,6,7,8-tetrahydro-4H-chromen-5-one (CAS 860611-39-8)
- 5-Amino-2-(methylthio)pyrimidin-4(3H)-one (CAS 6627-25-4)
- 2-Amino-7-bromo-4-(4-chloro-3-nitrophenyl)-4H-benzo[g]chromene-3-carbonitrile (CAS 861208-32-4)
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Recommended Standards
- (2S,3S,4S,5S,6R)-2-(2-azidoethoxy)-4-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diyl dibenzoate (CAS 872100-81-7)
- 2-Phenyl-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)acetonitrile (CAS 51371-34-7)
- 3-Indolyl-β-D-cellobioside (CAS 914912-14-4)
- Aripiprazole Impurity 43 (CAS CATO-C4X-100843)
- (2-(Isobutoxycarbonyl)phenyl)boronic acid (CAS 1256345-85-3)
- 3-Bromo-5-cyclopropoxy-4-fluoropyridine (CAS 1243453-43-1)
- 4-[2-((Methyl-d3)-2-pyridinylamino)ethoxy]benzaldehyde (CAS 1189982-66-8)
- 2'-(1,3-Dioxolan-2-yl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 400750-15-4)
- 2,3-Dichloro-4-(ethylsulfonyl)-N-(2-methoxyphenyl)benzamide (CAS 477867-70-2)
- Finerenone Impurity 123 (CAS CATO-C4X-2880123)
- 2,5-dimethyl-1H,4H-thieno[2,3-d]pyrimidin-4-one (CAS 782462-55-9)
- 2-(2-Ethoxyphenyl)-8-methylquinoline-4-carboxylic acid (CAS 897566-11-9)
- (S)-5,5'-Dodecamethylenedioxy-2,2'-bis(diphenyl phosphino)biphenyl (CAS 1225281-44-6)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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