n-[(2-chloro-6-fluorophenyl)methyl]cyclopropanamine CAS 625437-36-7
| CAS No. | 625437-36-7 |
| Molecular Formula | C10H11ClFN |
| Molecular Weight | 199.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 199.65 g/mol gives n-[(2-chloro-6-fluorophenyl)methyl]cyclopropanamine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
n-[(2-chloro-6-fluorophenyl)methyl]cyclopropanamine (CAS 625437-36-7) is a high-purity analytical reference standard with the molecular formula C10H11ClFN and a molecular weight of 199.65 g/mol.
The molecular framework of n-[(2-chloro-6-fluorophenyl)methyl]cyclopropanamine (C10H11ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), n-[(2-chloro-6-fluorophenyl)methyl]cyclopropanamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11ClFN |
| Molecular Weight | 199.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related n Standards
- 1-(3-Chloro-4-fluorophenyl)pyrrolidine (CAS 1000339-33-2)
- N-[(2-Chloro-4-fluorophenyl)methyl]cyclopropanamine (CAS 1016534-10-3)
- 1-(2-Chloro-6-fluorobenzyl)cyclopropan-1-amine (CAS 1017133-42-4)
- (1-(2-Chloro-6-fluorophenyl)cyclopropyl)methanamine (CAS 1039952-82-3)
- 1-(2-Chloro-6-fluorophenyl)cyclobutanamine (CAS 1094341-12-4)
- 3-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1156168-46-5)
- 5-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1156168-88-5)
- 4-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1157338-17-4)
Recommended Standards
- N-[(2-Chloro-3-fluorophenyl)methyl]cyclopropanamine (CAS 878001-23-1)
- N-[(3-Chloro-2-fluorophenyl)methyl]cyclopropanamine (CAS 878001-21-9)
- 3-Chloro-N-(cyclopropylmethyl)-4-fluoroaniline (CAS 939757-92-3)
- (5-methyl-1,2-oxazol-3-yl)methanesulfonyl chloride (CAS 1000932-59-1)
- 5-Aminooctahydrocyclopenta[c]pyrrole-5-carboxylic acid (CAS 1172692-76-0)
- 2-Bromo-4-methyl-nicotinic acid (CAS 65996-07-8)
- (1r,4s,6s)-5-(Tert-butoxycarbonyl)-7-(trifluoromethyl)-2-oxa-5-azabicyclo[4.1.0]heptane-4-carboxylic acid (CAS 1955485-41-2)
- 4-Acetyl-4-pentylcyclohexan-1-one (CAS 76921-65-8)
- (1Z,4E)-5-(2-{6-[(2,4-dichlorophenyl)methyl]pyridazin-3-yl}hydrazin-1-yl)-1-(thiophen-2-yl)penta-1,4-dien-3-one (CAS 860649-36-1)
- 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one (CAS 94284-66-9)
- 3-Amino-2-methylbenzoic Acid (CAS 52130-17-3)
- N-(piperidin-4-yl)pyridin-3-amine (CAS 63260-35-5)
- 3-(3,5-dimethyl-1H-pyrazol-4-yl)butanoic acid (CAS 1423025-74-4)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
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