1,2,4,5-Tetrafluoro-3-nitrobenzene CAS 6257-03-0
| CAS No. | 6257-03-0 |
| Molecular Formula | C6HF4NO2 |
| Molecular Weight | 195.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.07 g/mol gives 1,2,4,5-Tetrafluoro-3-nitrobenzene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1,2,4,5-Tetrafluoro-3-nitrobenzene (CAS 6257-03-0) is a high-purity analytical reference standard with the molecular formula C6HF4NO2 and a molecular weight of 195.07 g/mol.
Structurally, 1,2,4,5-Tetrafluoro-3-nitrobenzene (C6HF4NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 195.07 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6HF4NO2 |
| Molecular Weight | 195.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Tetrafluoro Standards
- 1,2,3,4-Tetrafluoro-5-nitrobenzene (CAS 5580-79-0)
- 1,2,3,5-Tetrafluoro-4-nitrobenzene (CAS 314-41-0)
- 2,3,5,6-tetrafluoro-4-methoxyaniline (CAS 1643-71-6)
- (2,3,4,5-Tetrafluoro-6-methylphenyl)methanol (CAS 79537-94-3)
- 2,3,5,6-Tetrafluoro-4-methylanisole (CAS 3150-40-1)
- 2,3,5,6-Tetrafluoro-N,N-dimethylpyridin-4-amine (CAS 2875-13-0)
- 2,3,4,5-Tetrafluoro-6-hydroxybenzaldehyde (CAS 502762-93-8)
- 2,3,5,6-Tetrafluoro-4-hydroxybenzaldehyde (CAS 24336-73-0)
Recommended Standards
- 2,4-Dichloro-5-(methylthio)pyrimidine (CAS 7401-98-1)
- 2-Chloro-1-(3-chlorothiophen-2-yl)ethanone (CAS 62673-63-6)
- 1-(4,5-Dichlorothiophen-2-yl)ethanone (CAS 57681-59-1)
- 2-Chloro-1-(5-chlorothiophen-2-yl)ethan-1-one (CAS 42445-55-6)
- Ethyl 2-(2-Chloro-3-methyl-4-pyridyl)acetate (CAS 1261471-41-3)
- 2-Bromo-5H-indeno[1,2-d]pyrimidine (CAS 1823584-57-1)
- 3,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1359968-87-8)
- [2-(4-Fluorophenyl)ethyl](4-nitrobenzyl)amine hydrobromide (CAS 1609400-18-1)
- Atrasentan Impurity 168 (CAS 1059043-43-4)
- Potassium 5,6-diaminonaphthalene-1,3-disulfonate (CAS 307495-30-3)
- N-(3,4-Dimethylphenyl)-4-nitrobenzenesulfonamide (CAS 16937-24-9)
- N-ethyl-2-(2-ethylpiperidin-1-yl)ethan-1-amine (CAS 933738-32-0)
- N-(6-Bromobenzo[d]thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide (CAS 1013756-96-1)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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