2,6,7-Trimethoxyquinoline CAS 6278-88-2
| CAS No. | 6278-88-2 |
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,6,7-Trimethoxyquinoline.
2,6,7-Trimethoxyquinoline (CAS 6278-88-2) is a high-purity analytical reference standard with the molecular formula C12H13NO3 and a molecular weight of 219.24 g/mol.
2,6,7-Trimethoxyquinoline (C12H13NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Trimethoxyquinoline Standards
Recommended Standards
- 2-(Tert-butylamino)-5-nitrobenzonitrile (CAS 945299-05-8)
- 2-[(2-nitrophenyl)methyl]cyclopentan-1-one (CAS 548461-24-1)
- 2-(tert-Butyl)-7-nitro-2H-indazole (CAS 61063-07-8)
- 2-[(2-nitrothiophen-3-yl)sulfanyl]acetic acid (CAS 77151-59-8)
- 1,5-Dibromo-2-chloro-3-(trifluoromethoxy)benzene (CAS 1000578-24-4)
- 2-(3-Ethoxyphenyl)morpholine (CAS 1017480-71-5)
- Trimethylsilyl 2-(dimethoxyphosphoryl)acetate (CAS 85169-29-5)
- 5-(Isopropyl(methyl)amino)-2,2-dimethylpentanoic acid (CAS 1491742-97-2)
- m-Carboxycinnamic acid bishydroxamide (CAS 174664-65-4)
- 2-Ketoglutarate dimethyl ester (CAS 13192-04-6)
- (3-Bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)methanamine (CAS 2387602-46-0)
- 2-Amino-6-chloro-3-(difluoromethyl)isonicotinic acid (CAS 1806807-71-5)
- 5-Bromoquinoline-2,4(1H,3H)-dione (CAS 914224-25-2)
- Hexapeptide-11 (CAS 100684-36-4)
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