2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol CAS 628322-95-2

Purity 97%+In StockPharmaceutical Standards
CAS No.628322-95-2
Molecular FormulaC10H10BrFN2O
Molecular Weight273.10 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol CAS 628322-95-2 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol.

2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol (CAS 628322-95-2), molecular formula C10H10BrFN2O and molecular weight 273.10 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol (C10H10BrFN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC10H10BrFN2O
Molecular Weight273.10 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF/Br-containing
Nitrogen Atoms2

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