Hydroxychloroquine Impurity 20 CAS 630067-21-9
| CAS No. | 630067-21-9 |
| Molecular Formula | C10H5Cl2NO2 |
| Molecular Weight | 242.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Hydroxychloroquine Impurity 20 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 242.06 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Hydroxychloroquine Impurity 20 (CAS 630067-21-9), a pharmacopoeial impurity reference standard (molecular formula C10H5Cl2NO2, MW 242.06 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Hydroxychloroquine Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5Cl2NO2 |
| Molecular Weight | 242.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine EP Impurity F (CAS 6281-58-9)
- Hydroxychloroquine impurity 83 (CAS CATO-C4X-183583)
- Hydroxychloroquine impurity 62 (CAS CATO-C4X-183562)
- Hydroxychloroquine Impurity 28 (CAS CATO-C4X-183528)
- Hydroxychloroquine Impurity 19 (CAS 23834-01-7)
- Hydroxychloroquine Impurity 70 (CAS 56881-09-5)
- Hydroxychloroquine impurity 84 (CAS CATO-C4X-183584)
- Hydroxychloroquine RC 2 (CAS 860715-45-3)
Recommended Standards
- 898760-53-7 (2,3-Dichlorophenyl)(1,3-oxazol-2-yl)methanone DTXSID80642109 (CAS 898760-53-7)
- Quinclorac (CAS 84087-01-4)
- 50872-45-2 5-(4-Chlorophenyl)isoxazole-3-carbonyl chloride MFCD04969970 (CAS 50872-45-2)
- 3-Bromo-6-methoxy-1H-indazol-4-amine (CAS 1000341-23-0)
- Erlotinib impurity 128 (CAS 183321-84-8)
- Tipiracil Impurity 12 (CAS 99478-59-8)
- Cefdinir Impurity 68 (CAS CATO-C4X-121068)
- 2-(7-Bromopyrrolo[2,1-f][1,2,4]triazin-2-yl)-N,N-dimethylethan-1-amine (CAS 2091620-81-2)
- 4-Amino-2-bromo-5-fluorobenzonitrile (CAS 1850856-63-1)
- Itopride Impurity 21 (CAS 199679-32-8)
- Ethyl 2-hydroxy-2-(oxetan-3-yl)acetate (CAS 1509910-39-7)
- Indoline-7-carboxylic acid (CAS 15861-40-2)
- Neoruscogenin (CAS 17676-33-4)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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