6-Fluoro-3-(trifluoromethyl)-2,3-dihydroquinolin-4(1H)-one CAS 63273-37-0
| CAS No. | 63273-37-0 |
| Molecular Formula | C10H7F4NO |
| Molecular Weight | 233.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 6-Fluoro-3-(trifluoromethyl)-2,3-dihydroquinolin-4(1H)-one (CAS 63273-37-0), a certified reference material (molecular formula C10H7F4NO, MW 233.16 g/mol) for analytical method development and quality control.
The molecular framework of 6-Fluoro-3-(trifluoromethyl)-2,3-dihydroquinolin-4(1H)-one (C10H7F4NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F4NO |
| Molecular Weight | 233.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- (E)-1,1,1-trifluoro-4-((2-fluorophenyl)amino)but-3-en-2-one (CAS 380430-76-2)
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- 2-amino-5-(difluoromethoxy)-4-methoxybenzoic acid (CAS 1096901-30-2)
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- N-(2-Fluorobenzyl)-1-(p-tolyl)methanamine (CAS 892594-58-0)
- 3-(1-Ethyl-1h-imidazol-2-yl)propan-1-amine (CAS 1343718-36-4)
- 3,4-Dihydronaphthalen-1(2H)-one O-((4-methoxyphenyl)sulfonyl) oxime (CAS 145609-81-0)
- Dithioterephthalic acid (CAS 1076-98-8)
- 2,4-dichloro-7-nitro-1,3-benzothiazole (CAS 70200-91-8)
- 1-(3,4-Dichlorophenyl)-2-((4-methoxyphenyl)sulfonyl)ethan-1-ol (CAS 320422-59-1)
- tert-Butyl(4-amino-3-methoxyphenyl)carbamate (CAS 487065-22-5)
- 3-(((2,6-Dichlorobenzyl)thio)methyl)-4-ethyl-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazole (CAS 344270-95-7)
- N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-((2-nitrobenzyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 64481-97-6)
- Peptide 442 (CAS CATO-CPTD788442)
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