Aripiprazole Impurity 37 CAS 63386-61-8
| CAS No. | 63386-61-8 |
| Molecular Formula | C10H12Cl2N2 |
| Molecular Weight | 231.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 231.12 g/mol gives Aripiprazole Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Aripiprazole Impurity 37 (CAS 63386-61-8, C10H12Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Aripiprazole Impurity 37 (C10H12Cl2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aripiprazole Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12Cl2N2 |
| Molecular Weight | 231.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Aripiprazole Standards
- Aripiprazole Impurity N22（Aripiprazole EP Impurity B） (CAS 41202-77-1)
- Aripiprazole 3,4-Dichlorophenyl Piperazine Impurity (CAS 57260-67-0)
- Aripiprazole Related Compound B (CAS 889443-20-3)
- Aripiprazole-d (CAS 1185116-86-2)
- Aripiprazole Impurity 16 (CAS 23478-25-3)
- Aripiprazole Impurity 28 (CAS 1359829-23-4)
- Aripiprazole Impurity 43 (CAS 54147-91-0)
- Aripiprazole Impurity 40 (CAS CATO-C4X-100840)
Recommended Standards
- 898766-60-4 1-(2,5-Dichlorophenyl)-2,2-dimethylpropan-1-one DTXSID80642482 (CAS 898766-60-4)
- 1-(2,5-Dichlorophenyl)piperazine (CAS 1013-27-0)
- Diethylene Glycol Bis(2-chloroethyl) Ether (CAS 638-56-2)
- Cariprazine Impurity 14 (CAS 55827-50-4)
- Tramadol Hydrochloride EP Impurity E (CAS CATO-C4X-149812)
- Plerixafor Impurity 44 (CAS 1254176-45-8 (free base))
- Topiroxostat Impurity 28 (CAS 1992028-94-0)
- Tert-butyl (S)-(2-(piperidin-3-yl)ethyl)carbamate (CAS 1217625-83-6)
- 2,6-Difluoro-4-nitrophenacyl bromide (CAS 1803827-60-2)
- 3-Cyclopentylpiperidine (CAS 794533-53-2)
- tert-Butyl (2-amino-3-formylphenyl)carbamate (CAS 1823276-66-9)
- Tamsulosin Impurity 68 (CAS 1027854-97-2)
- 2-((2,6-Dichlorobenzyl)thio)-1-methyl-4,5-diphenyl-1H-imidazole (CAS 339277-22-4)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
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