Tert-butyl 4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate CAS 634464-86-1
| CAS No. | 634464-86-1 |
| Molecular Formula | C17H22F3NO3 |
| Molecular Weight | 345.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tert-butyl 4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Tert-butyl 4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate (CAS 634464-86-1), molecular formula C17H22F3NO3 and molecular weight 345.36 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Tert-butyl 4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 345.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C17H22F3NO3 |
| Molecular Weight | 345.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Tert-butyl 4-hydroxy-4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate (CAS 871112-34-4)
- Linagliptin impurity 97 (CAS CATO-C4X-110197)
- tert-Butyl 4-(4-(trifluoromethyl)phenoxy)piperidine-1-carboxylate (CAS 287952-08-3)
- Nirmatrelvir Impurity 5 (CAS CATO-C4X-28745)
- 4-Acetyl-5-methyl-3-propyl-1h-pyrrole-2-carboxylic acid (CAS 1181894-93-8)
- 4-(4-ethylpiperazin-1-yl)butan-1-ol (CAS 110439-00-4)
- 2-Chloro-4-(1-piperazinyl)-benzaldehyde (CAS 20011-18-1)
- Ethyl 3-[(4-aminopiperidin-1-yl)methyl]piperidine-1-carboxylate hydrochloride (CAS 1257850-47-7)
- Methyl 2-(2-chloropyrimidin-5-yl)acetate (CAS 1261803-28-4)
- 3-methyl-1-(pyrimidin-4-yl)-1H-pyrazol-5-amine (CAS 1502933-87-0)
- (4r)-3,4-Dihydro-2h-1-benzothiopyran-4-ol (CAS 120466-74-2)
- Methyl 2,3-dichloro-6-(difluoromethoxy)benzoate (CAS 1803712-94-8)
- 2-Chloro-4-(trichloromethyl)pyrimidine (CAS 701-28-0)
- Des-[Oct-γ-Glu-AEEA-AEEA]-Semaglutide (CAS CATO-C4X-2226112)
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