Picolinic acid hydrochloride CAS 636-80-6
| CAS No. | 636-80-6 |
| Molecular Formula | C6H5NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Picolinic acid hydrochloride is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Picolinic acid hydrochloride (CAS 636-80-6), molecular formula C6H5NO2HCl and molecular weight 159.57 g/mol, is a CATO reference standard with documented purity and traceability.
Picolinic acid hydrochloride (C6H5NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5NO2 HCl |
| Molecular Weight | 159.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Picolinic Standards
- Picolinic Anilide (CAS 10354-53-7)
- 2-Picolinic-d4 Acid (CAS 284487-61-2)
- Picolinic acid hydrate (CAS 354527-55-2)
- Picolinic acid sodium salt (CAS 57665-05-1)
- 73771-11-6 Picolinic acid, 4-chloro-, hydrazide 2-Pyridinecarboxylic acid, 4-chloro-, hydrazide (9CI) 4-22-00-00334 (Beilstein Handbook Reference) BRN 0136291 4-Chloropicolinic acid hydrazide NSC 146826 (CAS 73771-11-6)
- picolinic acid 2-chlorobenzylamide (CAS 923229-50-9)
- Picolinic Acid (CAS 98-98-6)
Recommended Standards
- 4-(Chloromethyl)-N-(5-methylisoxazol-3-yl)benzamide (CAS 261704-37-4)
- n-(2-(Pyridin-2-yl)ethyl)pentan-3-amine (CAS 1019564-57-8)
- N-(4-methoxybenzo[d]thiazol-2-yl)benzamide (CAS 35412-20-5)
- 4-((Diethylamino)methyl)-5-isobutyl-2-methylfuran-3-carboxylic acid (CAS 435341-96-1)
- 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazol-2-yl)pyrrolidin-2-one (CAS 1353316-02-5)
- (4R,4'R)-2,2'-(Pentane-3,3-diyl)bis(4-phenyl-4,5-dihydrooxazole) (CAS 195515-48-1)
- N-(2-aminoethyl)-5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazole-2-carboxamide (CAS 924871-49-8)
- 2-chloro-n-methoxy-n-methyl-4-nitrobenZamide (CAS 179687-05-9)
- 5-Methyl-2-((tetrahydro-2H-pyran-2-yl)methoxy)aniline (CAS 946682-86-6)
- Anorexigenic Peptide (CAS 69275-10-1)
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