(E)-4-chloro-N'-(3-(4-chlorophenyl)acryloyl)benzohydrazide CAS 637306-61-7
| CAS No. | 637306-61-7 |
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 335.18 g/mol gives (E)-4-chloro-N'-(3-(4-chlorophenyl)acryloyl)benzohydrazide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(E)-4-chloro-N'-(3-(4-chlorophenyl)acryloyl)benzohydrazide (CAS 637306-61-7), molecular formula C16H12Cl2N2O2 and molecular weight 335.18 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, (E)-4-chloro-N'-(3-(4-chlorophenyl)acryloyl)benzohydrazide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 335.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-4-chloro-N'-(3-(4-chlorophenyl)acryloyl)benzohydrazide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 1-(2,4-Dichloro-6-hydroxy-3-methoxyphenyl)naphthalen-2-ol (CAS 1980086-78-9)
- (3Z)-1-[(3,4-Dichlorophenyl)methyl]-3-(methoxyimino)-2,3-dihydro-1H-indol-2-one (CAS 477853-28-4)
- 2'-(iodomethyl)spiro[indoline-3,4'-tetrahydrofuran]-2-one (CAS 2243652-57-3)
- Ethyl 7-Fluoroindole-3-acetate (CAS 1601476-86-1)
- 5,6-Dihydro-4H-pyrrolo[1,2-β]pyrazole-2-carboxylic acid (CAS 796729-03-8)
- 2-Amino-3-hydroxybutanoic acid (CAS 7004-04-8)
- Methyl 2-(4-(aminomethyl)phenyl)acetate hydrochloride (CAS 99075-25-9)
- 5-Ethyl-5-(hydroxymethyl)-1,3-dioxan-2-one (CAS 38802-97-0)
- trans-Cyclohexane-1,4-dicarbonyl dichloride (CAS 19988-54-6)
- (1H-imidazol-2-yl)(4-methoxyphenyl)methanone (CAS 68090-12-0)
- Anion Standard - Nitrate (CAS 14797-55-8)
- (S)-Benzyl 3-((2-hydroxyethyl)(methyl)amino)piperidine-1-carboxylate (CAS 1354009-50-9)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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