N-(3-(Difluoromethoxy)phenyl)nicotinamide hydrochloride CAS 64038-00-2
| CAS No. | 64038-00-2 |
| Molecular Formula | C13H10F2N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(3-(Difluoromethoxy)phenyl)nicotinamide hydrochloride (C13H10F2N2O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
N-(3-(Difluoromethoxy)phenyl)nicotinamide hydrochloride (CAS 64038-00-2) is a high-purity analytical reference standard with the molecular formula C13H10F2N2O2HCl and a molecular weight of 300.69 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures N-(3-(Difluoromethoxy)phenyl)nicotinamide hydrochloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H10F2N2O2 HCl |
| Molecular Weight | 300.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- 2-(2-(Difluoromethoxy)phenyl)ethan-1-ol (CAS 1000533-82-3)
- 4-(Difluoromethoxy)-2-iodoaniline (CAS 1000801-26-2)
- 3-(4-(Difluoromethoxy)phenyl)propanoic acid (CAS 1000932-18-2)
- 4-(Difluoromethoxy)-2-fluoroaniline (CAS 1003865-65-3)
- (4-(Difluoromethoxy)-2-fluorophenyl)boronic acid (CAS 1004775-34-1)
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- 1-(3-(Difluoromethoxy)phenyl)-3-(1,5-dimethyl-1H-pyrazol-4-yl)prop-2-en-1-one (CAS 1005647-45-9)
- Methyl 6-(4-(difluoromethoxy)phenyl)-3-methylisoxazolo[5,4-b]pyridine-4-carboxylate (CAS 1011396-51-2)
Recommended Standards
- Ethyl 2-fluoro-2-(piperidin-4-yl)acetate (CAS 874440-83-2)
- 2-(1H-benzo[d]imidazol-2-yl)-1-(4-fluorophenyl)ethan-1-amine hydrochloride (CAS 1279219-44-1)
- Methyl 6-hydroxy-5-(3-methoxy-2,4-dimethyl-6-(methylsulfonamido)phenyl)-2-naphthoate (CAS 1832514-22-3)
- N-(4-methoxyphenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 956742-03-3)
- N-(2-Chlorobenzyl)-4-(5-mercapto-1,3,4-oxadiazol-2-yl)benzenesulfonamide (CAS 917750-18-6)
- 3-Difluoromethoxy-6-(trifluoromethyl)pyridine-2-carboxylic acid (CAS 1227582-84-4)
- (1s,6s)-3-Azabicyclo[4.1.0]heptane-1-carboxylic acid hydrochloride (CAS 1485394-89-5)
- 1-Ethyl-7-(methoxymethyl)-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridine (CAS 1422133-59-2)
- 2-Propyl-DL-norvaline Hydrochloride (CAS 87113-22-2)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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