(1S,3S)-3-Amino-4-(difluoromethylene)cyclopentanecarboxylic acid CAS 640897-20-7
| CAS No. | 640897-20-7 |
| Molecular Formula | C7H9F2NO2 |
| Molecular Weight | 177.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(1S,3S)-3-Amino-4-(difluoromethylene)cyclopentanecarboxylic acid (CAS 640897-20-7), molecular formula C7H9F2NO2 and molecular weight 177.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (1S,3S)-3-Amino-4-(difluoromethylene)cyclopentanecarboxylic acid (C7H9F2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9F2NO2 |
| Molecular Weight | 177.15 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (5,5-Difluoro-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazol-3-yl)methanol (CAS 1823380-96-6)
- (S)-Methyl 4-(difluoromethylene)pyrrolidine-2-carboxylate (CAS 808154-66-7)
- 5-Ethynyl-2-(trifluoromethyl)thiazole (CAS 1695759-58-0)
- 1,1,1-Trifluoro-n,n-dimethylmethanesulfonamide (CAS 28048-17-1)
- 4-(dimethylamino)benzonitrile (CAS 1197-19-9)
- 2-(3,5-Bis(trifluoromethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (CAS 1380288-30-1)
- 2-Methyl-4-phenyl-1H-imidazole-1-carbonitrile (CAS 83505-78-6)
- [4-[2-(Dimethylamino)ethoxy]phenyl](4-hydroxyphenyl)methanone (CAS 173163-13-8)
- 5-Bromo-2-chloro-1H-indole-3-carboxylic acid (CAS 933740-77-3)
- Methyl 3-(Chloromethyl)-5-nitrobenzoate (CAS 142320-39-6)
- (E)-3-(Pyridin-3-yl)acrylohydrazide (CAS 173679-09-9)
- Pyrazinamide-d3 (CAS 1432059-16-9)
- 3-(Difluoromethyl)-5-iodo-2-(trifluoromethyl)pyridin-4-amine (CAS 1806894-34-7)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
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