Nilotinib Impurity 14 CAS 641571-12-2
| CAS No. | 641571-12-2 |
| Molecular Formula | C12H8F3N3 |
| Molecular Weight | 251.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C12H8F3N3, Nilotinib Impurity 14 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nilotinib Impurity 14 (CAS 641571-12-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H8F3N3 and a molecular weight of 251.21 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nilotinib Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8F3N3 |
| Molecular Weight | 251.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Nilotinib Standards
- Nilotinib Impurity 24 (CAS 641571-16-6)
- Nilotinib Hydrochloride Monohydrate EP Impurity A (CAS 641571-11-1)
- Nilotinib Bromo Impurity (CAS 54962-75-3)
- Nilotinib Impurity 15 (CAS 917391-28-7)
- Nilotinib Impurity 16 (CAS 641571-13-3)
- Nilotinib Impurity 17 (CAS 916975-92-3)
- Nilotinib Impurity 2 (CAS 943320-48-7)
- Nilotinib Impurity 19 (CAS CATO-C4X-125619)
Recommended Standards
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- Carbocisteine Impurity 34 (CAS CATO-C4X-201034)
- methyl 5-(2-fluorophenoxymethyl)-1,2-oxazole-3-carboxylate (CAS 932780-86-4)
- PPPA (CAS 113190-92-4)
- Prednisolone Impurity 41 (CAS CATO-C4X-173741)
- Amoxicillin EP Impurity L (CAS 1789703-32-7)
- Valsartan Impurity 111 (CAS CATO-C4X-1057111)
- (2-Fluoro-6-nitrophenyl)methanol (CAS 1643-60-3)
- 2-Amino-4-(bromomethyl)-6-(difluoromethyl)nicotinonitrile (CAS 1806841-37-1)
- tert-Butyl rac-(4aR,8aR)-6-oxooctahydro-2(1H)-isoquinolinecarboxylate (CAS 146548-14-3)
- (S)-6-Chloro-2,2-dimethylchroman-4-amine (CAS 1604257-62-6)
- 4,5-Dibenzylidene-1,2,3,4,5,6,7,8-octahydroacridine (CAS 32462-10-5)
- 7-Chloro-5-(methylthio)tetrazolo[1,5-c]pyrimidine (CAS 478258-52-5)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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