Papaverine EP Impurity E HCl (Tetrahydropapaverine HCl) CAS 6429-04-5
| CAS No. | 6429-04-5 |
| Molecular Formula | C20H25NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Papaverine EP Impurity E HCl (Tetrahydropapaverine HCl).
Papaverine EP Impurity E HCl (Tetrahydropapaverine HCl) (CAS 6429-04-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25NO4HCl and a molecular weight of 379.88 g/mol.
The molecular framework of Papaverine EP Impurity E HCl (Tetrahydropapaverine HCl) (C20H25NO4HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25NO4 HCl |
| Molecular Weight | 379.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Papaverine Standards
- Papaverine-d3 Hydrochloride (CAS 113718-66-4)
- Papaverine Impurity 37 (CAS 1207386-32-0)
- Papaverine Hydrochloride - Impurity E (CAS 13074-31-2)
- Papaverine EP Impurity F (CAS 139-76-4)
- Papaverine Impurity 35 (CAS 16637-56-2)
- Papaverine Impurity 14 Hcl (CAS 18694-10-5（free base）)
- Papaverine Impurity 17 (CAS 18783-43-2)
- Papaverine Impurity 2 (CAS 18813-60-0)
Recommended Standards
- Cefaclor Impurity 47 (CAS CATO-C4X-127047)
- Cefixime Impurity 34 (CAS CATO-C4X-113934)
- Citalopram Impurity 67 (CAS 4792-29-4)
- N,N-Dimethyl-1-(piperidin-4-yl)methanamine hydrochloride (CAS 172281-93-5)
- Dimethyl(p-tolyl)phosphane (CAS 20676-64-6)
- 1,3-16:1 D5DG (CAS 1246523-68-1)
- 4-(1H-1,2,3,4-tetrazol-1-yl)oxane-4-carboxylic acid (CAS 1909320-21-3)
- 1-(2-Chloropyridin-3-yl)-3-(p-tolyl)thiourea (CAS 69437-73-6)
- 2-(Difluoromethyl)-6-methylphenylhydrazine (CAS 1805894-39-6)
- D-[Phe]6-Liraglutide (CAS CATO-C4X-199235)
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