4-Chloro-2-(trifluoromethyl)aniline hydrochloride CAS 648415-76-3
| CAS No. | 648415-76-3 |
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-2-(trifluoromethyl)aniline hydrochloride is closely related to a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-Chloro-2-(trifluoromethyl)aniline hydrochloride (CAS 648415-76-3), molecular formula C7H5ClF3NHCl and molecular weight 232.03 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, fluorine/chlorine substitution, 4-Chloro-2-(trifluoromethyl)aniline hydrochloride is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 232.03 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-(trifluoromethyl)aniline hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF3N HCl |
| Molecular Weight | 232.03 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
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Recommended Standards
- ethyl (3S,3aS,6aR)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-3-carboxylate;hydrochloride (CAS 1147103-42-1)
- 2-Bromo-4-chloro-3-(trifluoromethyl)acetophenone (CAS 1807014-44-3)
- 2-Amino-3-bromo-5-chloropyridine (CAS 26163-03-1)
- Tributyl(2-selenophenyl)stannane (CAS 116886-71-6)
- 5-Bromo-N-cyclohexyl-N,4-dimethylpyridin-2-amine (CAS 1220029-11-7)
- Tert-butyl (6-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS 1309982-22-6)
- Roxadustat Impurity 177 (CAS CATO-C4X-2213177)
- (S,Z)-3-((E)-2-((1R,3AS,7aR)-1-((2R,5R,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol (CAS 90191-28-9)
- 2-(4-Nitrophenyl)-1-phenylethan-1-one (CAS 3769-82-2)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
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