4-Chloroquinazoline-6-carbaldehyde CAS 648449-05-2
| CAS No. | 648449-05-2 |
| Molecular Formula | C9H5ClN2O |
| Molecular Weight | 192.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Chloroquinazoline-6-carbaldehyde (CAS 648449-05-2) is a high-purity analytical reference standard with the molecular formula C9H5ClN2O and a molecular weight of 192.60 g/mol.
4-Chloroquinazoline-6-carbaldehyde (C9H5ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5ClN2O |
| Molecular Weight | 192.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroquinazoline Standards
- 2-Chloroquinazoline-4-carbaldehyde (CAS 944903-02-0)
- 4-Chloroquinazoline-2-carbaldehyde (CAS 944903-04-2)
- 6-Chloroquinazoline-2,4-diamine (CAS 18671-95-9)
- 7-Chloroquinazoline-2,4-diamine (CAS 27018-19-5)
- 8-Chloroquinazoline-2,4-diamine (CAS 923515-01-9)
- 4-Chloroquinazoline-8-carbonitrile (CAS 1231761-54-8)
- 4-Chloroquinazoline-7-carbonitrile (CAS 1260759-38-3)
- 2-Chloroquinazoline-6-carbonitrile (CAS 1388043-87-5)
Recommended Standards
- 5-Chloronaphthalene-1,4-dione (CAS 40242-15-7)
- 4-Chloronaphthalene-1,2-dione (CAS 6655-90-9)
- Cinnoline-6-carbonyl chloride (CAS 519141-64-1)
- 3-Chloroquinoxaline-2-carbaldehyde (CAS 49568-68-5)
- [4,4'-Bipyridine]-3,3'-diamine (CAS 69112-07-8)
- 5-ethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-amine hydrochloride (CAS 1787909-27-6)
- Ethyl 1-cyclopropyl-4,5-dioxopyrrolidine-3-carboxylate (CAS 1355233-36-1)
- 1-(4-Chlorophenyl)-2-(3,5-dibromo-1H-1,2,4-triazol-1-yl)ethan-1-one (CAS 914350-25-7)
- 1-(3,4-Dichlorophenyl)-3-(4-fluorophenyl)propan-1-one (CAS 898768-74-6)
- Octahydro-1H-cyclopenta[c]pyridine-6-carboxylic acid (CAS 1935175-69-1)
- 1-(5-(M-tolyl)-1,3,4-oxadiazol-2-yl)ethan-1-amine hydrochloride (CAS 1417635-64-3)
- 4-Chloro-n-(2-(dipropylamino)-2-phenylethyl)benzenesulfonamide (CAS 891014-19-0)
- N-methylnaphthalen-1-amine hydrochloride (CAS 4643-36-1)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
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