N5-(2-fluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide CAS 648859-61-4
| CAS No. | 648859-61-4 |
| Molecular Formula | C12H6ClF4N3O |
| Molecular Weight | 319.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N5-(2-fluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N5-(2-fluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 648859-61-4), molecular formula C12H6ClF4N3O and molecular weight 319.64 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C12H6ClF4N3O, N5-(2-fluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 319.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H6ClF4N3O |
| Molecular Weight | 319.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- N5-(4-fluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 680210-96-2)
- 1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-amine (CAS 941868-15-1)
- 3-[(3-fluorophenyl)methyl]-1-[(4-methylbenzene)sulfonyl]azetidine (CAS 1356678-71-1)
- 3-[(2-fluorophenyl)methyl]-1-[(4-methylbenzene)sulfonyl]azetidine (CAS 1356739-43-9)
- 2-(4-Fluorophenyl)-1-tosylpyrrolidine (CAS 298689-69-7)
- 4-((4-Fluorophenyl)thio)-N-(4-methoxyphenyl)butanamide (CAS 941925-12-8)
- 4-(4-Fluorophenyl)-5-((pyrimidin-2-ylthio)methyl)-4h-1,2,4-triazole-3-thiol (CAS 887205-28-9)
- (1-(4-Fluorophenyl)cyclopropyl)(1,5-dioxa-9-azaspiro[5.5]undecan-9-yl)methanone (CAS 1351613-07-4)
Recommended Standards
- 1-(1-(Thiophen-2-yl)ethylidene)-2-(2,4,6-trichlorophenyl)hydrazine (CAS 194923-67-6)
- 3-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-(3-methylphenyl)acrylamide (CAS 154563-44-7)
- 1-Chloro-4,8-dihydroxy-5-nitroanthracene-9,10-dione (CAS 61944-32-9)
- N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloropropanamide (CAS 937604-58-5)
- Cinacalcet Impurity 77 (CAS 1261456-46-5)
- 9,10,12,13-Tetrahydro-11H-9,10-endo-Cyclopropanthracene (CAS 30122-20-4)
- (3-((1H-pyrazol-1-yl)methyl)-4-methoxyphenyl)methanamine (CAS 956352-90-2)
- 3-(4-Fluorophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 878426-96-1)
- 1-(1-Methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)methanamine (CAS 1152858-36-0)
- Teneligliptin impurity 32 (CAS CATO-C4X-176032)
- 3-Bromo-2-chloro-4-fluorobenzonitrile (CAS 2091679-54-6)
- 1-Methyl-1H-pyrazole-4-carbaldehyde oxime (CAS 42849-80-9)
- 2-(Azulen-2-yl)furan (CAS 654075-85-1)
- MCH-Gene-Overprinted-Polypeptide-14 (rat) (H-4746.0500) (CAS 182917-44-8)
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