1,1,1-trifluoro-3-[(pyrimidin-2-ylamino)methylene]pentane-2,4-dione CAS 649665-82-7
| CAS No. | 649665-82-7 |
| Molecular Formula | C10H8F3N3O2 |
| Molecular Weight | 259.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1,1,1-trifluoro-3-[(pyrimidin-2-ylamino)methylene]pentane-2,4-dione.
1,1,1-trifluoro-3-[(pyrimidin-2-ylamino)methylene]pentane-2,4-dione (CAS 649665-82-7) is a high-purity analytical reference standard with the molecular formula C10H8F3N3O2 and a molecular weight of 259.18 g/mol.
The molecular framework of 1,1,1-trifluoro-3-[(pyrimidin-2-ylamino)methylene]pentane-2,4-dione (C10H8F3N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1,1,1-trifluoro-3-[(pyrimidin-2-ylamino)methylene]pentane-2,4-dione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8F3N3O2 |
| Molecular Weight | 259.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related trifluoro Standards
- 2-(4,4,4-Trifluoro-3-oxo-but-1-enylamino)-benzoic acid (CAS 380430-75-1)
- (R)-2,2,2-trifluoro-1-(3-(trifluoromethoxy)phenyl)ethan-1-amine (CAS 1212922-33-2)
- (R)-2,2,2-trifluoro-1-(4-(trifluoromethoxy)phenyl)ethan-1-amine (CAS 1213147-94-4)
- (S)-2,2,2-trifluoro-1-(3-(trifluoromethoxy)phenyl)ethan-1-amine (CAS 1213451-78-5)
- (S)-2,2,2-trifluoro-1-(4-(trifluoromethoxy)phenyl)ethan-1-amine (CAS 1213496-87-7)
- 2,2,2-Trifluoro-1-(2-(trifluoromethoxy)phenyl)ethanamine (CAS 1270440-28-2)
- 2,2,2-trifluoro-1-[4-(trifluoromethoxy)phenyl]ethan-1-amine (CAS 1270479-61-2)
- 2,2,2-Trifluoro-1-(3-(trifluoromethoxy)phenyl)ethanamine (CAS 1270547-47-1)
Recommended Standards
- (Z)-4-oxo-4-((3-(trifluoromethyl)phenyl)amino)but-2-enoic acid (CAS 53616-18-5)
- 1-Acetyl-6-(trifluoromethoxy)indolin-2-one (CAS 2141958-75-8)
- (3-(4-(Trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methanamine (CAS 847868-59-1)
- 2-(2-(Trifluoromethoxy)ethyl)isoindoline-1,3-dione (CAS 329710-82-9)
- 2-Amino-2-cyclohexylpropanoic acid (CAS 6635-13-8)
- 1-(3,4-Dichlorobenzyl)-3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one (CAS 338755-28-5)
- 1-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1h-pyrazole-3-carboxylic acid (CAS 861151-23-7)
- 2-(Difluoromethyl)-3-iodo-5-(trifluoromethoxy)pyridine-4-carboxylic acid (CAS 1804917-06-3)
- (3-Cyanopropyl)hydrobis(triphenylphosphine)platinum (CAS 61344-63-6)
- Dotinurad Impurity 238 (CAS CATO-C4X-2494238)
- 2-(4-(Difluoromethyl)-2,5-difluoropyridin-3-yl)acetonitrile (CAS 1805008-50-7)
- Benzyl (3aR,7aS)-2-oxooctahydro-5H-pyrrolo[3,2-c]pyridine-5-carboxylate (CAS 2211132-40-8)
- 2-Bromo-5-(3,3-difluoropyrrolidin-1-yl)benzonitrile (CAS 1627693-34-8)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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