3-Bromo-5-methylthiophene-2-carbonitrile CAS 651034-29-6
| CAS No. | 651034-29-6 |
| Molecular Formula | C6H4BrNS |
| Molecular Weight | 202.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Bromo-5-methylthiophene-2-carbonitrile.
3-Bromo-5-methylthiophene-2-carbonitrile (CAS 651034-29-6) is a high-purity analytical reference standard with the molecular formula C6H4BrNS and a molecular weight of 202.07 g/mol.
The molecular framework of 3-Bromo-5-methylthiophene-2-carbonitrile (C6H4BrNS) is characterized by a nitrile group, sulfur-containing functionality, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BrNS |
| Molecular Weight | 202.07 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 2-Bromo-4-ethynyl-5-methylthiazole (CAS 1564886-07-2)
- 2-Bromo-N-methylethane-1-sulfonamide (CAS 1785584-02-2)
- 1-bromo-N,N-dimethylmethanesulfonamide (CAS 51270-39-4)
- 4-Bromo-3-methylthiophene-2-carbonitrile (CAS 266338-06-1)
- 5-Bromo-3-methylthiophene-2-carbonitrile (CAS 38239-48-4)
- 5-Bromo-4-methylthiophene-2-carbonitrile (CAS 304854-52-2)
- 5-Bromo-2-(methoxymethyl)pyridine (CAS 1000787-43-8)
- 5-Bromo-N-ethylpyrazin-2-amine (CAS 1001050-18-5)
Recommended Standards
- 3-(Bromomethyl)thiophene-2-carbonitrile (CAS 99708-88-0)
- 3-Bromopropane-1-sulfonamide (CAS 88496-95-1)
- 2-(5-Bromothiophen-2-yl)acetonitrile (CAS 71637-37-1)
- 2-(3-Bromothiophen-2-yl)acetonitrile (CAS 209796-27-0)
- 2-(3-Amino-4-chloro-1h-pyrazol-1-yl)-N,N-dimethylacetamide (CAS 1339763-35-7)
- Methyl 2-(methoxymethyl)-2'-methyl-[1,1'-biphenyl]-4-carboxylate (CAS 1141473-85-9)
- Anion Standard - Nitrite (CAS 14797-65-0)
- tert-Butyl 2-(6-(diethylamino)pyridin-3-yl)pyrrolidine-1-carboxylate (CAS 1352495-80-7)
- 4-(4-Bromophenyl)piperidine-4-carbonitrile (CAS 1255666-69-3)
- 2-Chloro-1-(2,5-dimethylthiophen-3-yl)ethan-1-one (CAS 31772-43-7)
- 2-(4-(5-Ethoxy-4-phenyloxazol-2-yl)phenyl)acetic acid (CAS 80589-72-6)
- N-(4-(5-Bromothiophen-2-yl)thiazol-2-yl)-1-naphthamide (CAS 476211-62-8)
- N-Hydroxy-5-(naphthalen-2-yloxy)pentanamide (CAS 96014-73-2)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
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