2,3,5,6-Tetrafluoro-4-methylbenzoic acid CAS 652-32-4
| CAS No. | 652-32-4 |
| Molecular Formula | C8H4F4O2 |
| Molecular Weight | 208.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,3,5,6-Tetrafluoro-4-methylbenzoic acid.
2,3,5,6-Tetrafluoro-4-methylbenzoic acid (CAS 652-32-4) is a high-purity analytical reference standard with the molecular formula C8H4F4O2 and a molecular weight of 208.11 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,3,5,6-Tetrafluoro-4-methylbenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F4O2 |
| Molecular Weight | 208.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Tetrafluoro Standards
- 5,6,7,8-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine (CAS 1743-87-9)
- 2,3,5,6-Tetrafluoro-4-methoxybenzaldehyde (CAS 19161-44-5)
- 2,2,3,3-Tetrafluoro-2,3-dihydro-1,4-benzodioxine (CAS 94767-47-2)
- 2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-5-amine (CAS 103082-67-3)
- 2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-6-amine (CAS 114851-31-9)
- (2,3,5,6-tetrafluoro-4-pyridinyl)acetic acid (CAS 65697-73-6)
- 3,4,4,4-Tetrafluoro-3-(trifluoromethoxy)but-1-yne (CAS 261760-14-9)
- 2,3,4,5-Tetrafluoro-6-hydroxybenzoic acid (CAS 14742-36-0)
Recommended Standards
- 2,3,4,5-Tetrafluorophenylacetic Acid (CAS 261952-21-0)
- 2,3,5,6-Tetrafluorophenylacetic Acid (CAS 3516-91-4)
- 2-Fluoro-3-hydroxy-4-(trifluoromethyl)benzaldehyde (CAS 2379321-61-4)
- 2-(Methacryloyloxy)ethyl phosphate (CAS 52628-03-2)
- 1-(2-Bromoethoxy)-3,5-dichlorobenzene (CAS 18800-31-2)
- Trimethylsilyl trifluoromethanesulfonate (CAS 27607-77-8)
- n-((1h-Pyrazol-3-yl)methyl)-3-ethyl-1,2,4-thiadiazol-5-amine (CAS 1480175-59-4)
- 2-Chloro-N'-methyl-N'-(6-methylpyridin-2-yl)acetohydrazide (CAS 924867-43-6)
- 21-Aminoepothilone B (CAS 280578-49-6)
- N-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-3-isopropoxypropan-1-amine hydrochloride (CAS 1856044-20-6)
- 1-Benzyl-5-chloro-1H-imidazole hydrochloride (CAS 129309-09-7)
- (R)-1-Boc-3-((dimethylamino)methyl)pyrrolidine (CAS 859027-48-8)
- 2-(Aminomethyl)-6-bromo-3-cyano-5-(difluoromethyl)pyridine (CAS 1806994-29-5)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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