5-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile CAS 65281-79-0
| CAS No. | 65281-79-0 |
| Molecular Formula | C10H10ClN5 |
| Molecular Weight | 235.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile (CAS 65281-79-0), molecular formula C10H10ClN5 and molecular weight 235.67 g/mol, is a CATO reference standard with documented purity and traceability.
5-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile (C10H10ClN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(tert-Butylamino)-6-chloropyrazine-2,3-dicarbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10ClN5 |
| Molecular Weight | 235.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
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Recommended Standards
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- 4-Chloro-N-methyl-1-phenyl-1H-pyrazole-5-carboxamide (CAS 318497-92-6)
- 5-Benzyl-3-methylisoxazole-4-carbonyl chloride (CAS 91961-44-3)
- 6,7-Dinitro-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid (CAS 66411-42-5)
- 3-(Trifluoromethyl)-N-{4-[3-(trifluoromethyl)benzenesulfonyl]phenyl}benzamide (CAS 339104-90-4)
- 3-Ethoxy-4-((5-methylthieno[2,3-d]pyrimidin-4-yl)amino)benzamide (CAS 917908-06-6)
- (S)-2-Amino-3-(4-chloro-2-fluorophenyl)propanoic acid (CAS 185837-15-4)
- 3,5-Dichloro-1H-pyrrolo[2,3-b]pyridine (CAS 1190317-53-3)
- Ethyl 2-ethyl-3-methyl-3-propyloxirane-2-carboxylate (CAS 1513364-05-0)
- 1-(Furan-2-yl)-3-((4-phenoxyphenyl)amino)propan-1-one (CAS 724753-95-1)
- Selegiline EP Impurity E (CAS 4528-51-2)
- 3-(1-Methyl-2,4-dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)propanoic acid (CAS 1708079-98-4)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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