Calcitriol Impurity 10 CAS 65445-15-0
| CAS No. | 65445-15-0 |
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Calcitriol Impurity 10 (CAS 65445-15-0) is a certified pharmaceutical impurity reference standard with the molecular formula C27H44O2 and a molecular weight of 400.64 g/mol.
Calcitriol Impurity 10 (C27H44O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Calcitriol Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
Related Calcitriol Standards
- Calcitriol Impurity 11 (CAS 41461-13-6)
- Calcitriol Impurity 33 (CAS 104651-70-9)
- Calcitriol Impurity 61 (CAS CATO-C4X-151061)
- Calcitriol impurity 53 (CAS CATO-C4X-151053)
- Calcitriol Impurity 30 (CAS 69389-87-3)
- Calcitriol Impurity 63 (CAS CATO-C4X-151063)
- Calcitriol Impurity 64 (CAS CATO-C4X-151064)
- Calcitriol Impurity 65 (CAS CATO-C4X-151065)
Recommended Standards
- Alfacalcidol impurity 9 (CAS CATO-C4X-13939)
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- Calcifediol Impurity 32 (CAS 2963746-77-0)
- Alfacalcidol Impurity 31 (CAS CATO-C4X-139331)
- (Z)-Ceftizoxime Open Ring Impurity 2 (CAS CATO-C4X-179330)
- Atrasentan Impurity 201 (CAS 1797510-53-2)
- Remdesivir Impurity 49 (CAS CATO-C4X-210049)
- 5-Cyano-N,N-dimethylpyridine-2-sulfonamide (CAS 1334493-12-7)
- Ethyl 6-benzyl-7-chloro-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 1065082-00-9)
- 2-((Cyclopropyl(thiophen-2-yl)methyl)amino)-N-isopropylacetamide (CAS 1274523-10-2)
- 2,4-Dichlorofluorobenzene (CAS 1435-48-9)
- Geodin (CAS 427-63-4)
- 5-Bromo-6-(ethylamino)pyrimidin-4(3H)-one (CAS 1601205-44-0)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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