2-Chloro-N-(2-(trifluoromethoxy)phenyl)acetamide CAS 656227-27-9
| CAS No. | 656227-27-9 |
| Molecular Formula | C9H7ClF3NO2 |
| Molecular Weight | 253.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Chloro-N-(2-(trifluoromethoxy)phenyl)acetamide (CAS 656227-27-9) is a high-purity analytical reference standard with the molecular formula C9H7ClF3NO2 and a molecular weight of 253.61 g/mol.
2-Chloro-N-(2-(trifluoromethoxy)phenyl)acetamide (C9H7ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H7ClF3NO2 |
| Molecular Weight | 253.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- Ethyl 2-chloro-5-(trifluoromethyl)nicotinate (CAS 1188265-81-7)
- Ethyl 4-chloro-6-(trifluoromethyl)picolinate (CAS 1196145-47-7)
- Ethyl 2-chloro-6-(trifluoromethyl)isonicotinate (CAS 1196154-43-4)
- Ethyl 3-chloro-4-(trifluoromethyl)picolinate (CAS 1198475-44-3)
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- Ethyl 5-chloro-2-(trifluoromethyl)nicotinate (CAS 1211587-70-0)
- Ethyl 3-chloro-6-(trifluoromethyl)picolinate (CAS 1214332-53-2)
- Ethyl 2-chloro-6-(trifluoromethyl)nicotinate (CAS 1214346-14-1)
Recommended Standards
- 2’-Chloro-4’-(trifluoromethoxy)acetanilide (CAS 256529-43-8)
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)propanoic acid (CAS 338422-79-0)
- 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}acetamide (CAS 246022-40-2)
- 3-Chloro-4-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,2-c]pyridazin-8-ol (CAS 2913147-27-8)
- 2,5-Difluoro-4-nitrobenzaldehyde (CAS 1160474-72-5)
- 2-(4,4-Dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1825371-73-0)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-chloro-2-fluorophenyl)methanone (CAS 898758-25-3)
- 5-Chloro-1-(2,6-dichlorobenzyl)-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 339009-09-5)
- 3-(3,4-Dimethoxybenzylidene)-5-(3,4-dimethoxyphenyl)furan-2(3H)-one (CAS 102474-18-0)
- (1-(2-Amino-6-chloropyrimidin-4-yl)piperidin-3-yl)methanol (CAS 1197569-96-2)
- 6-Benzyl-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (CAS 89889-83-8)
- 3-{[(9h-fluoren-9-ylmethoxy)carbonyl](propan-2-yl)amino}propanoic acid (CAS 1342594-74-4)
- Methyl 1-(2-fluorophenyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011400-05-7)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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