5-Methyl-1,2-benzisoxazol-3(2H)-one CAS 65685-49-6
| CAS No. | 65685-49-6 |
| Molecular Formula | C8H7NO2 |
| Molecular Weight | 149.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Methyl-1,2-benzisoxazol-3(2H)-one (CAS 65685-49-6), molecular formula C8H7NO2 and molecular weight 149.15 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, 5-Methyl-1,2-benzisoxazol-3(2H)-one is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 149.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Methyl-1,2-benzisoxazol-3(2H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7NO2 |
| Molecular Weight | 149.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 4-Methyl-1,2-benzisoxazol-3(2H)-one (CAS 1195552-73-8)
- 6-Methyl-1,2-benzisoxazol-3-ol (CAS 66571-26-4)
- 1,2-BENZISOXAZOL-3(2H)-ONE 1,2-BENZISOXAZOL-3-OL 1,2-BENZOXAZOL-3-OL 21725-69-9 3-HYDROXY-1,2-BENZISOXAZOLE AS06287 benzo[d]isoxazol-3-ol (CAS 21725-69-9)
- 1,2-Benzisoxazol-6-ol (CAS 65685-55-4)
- 1,2-Benzisoxazol-3-amine (CAS 36216-80-5)
- 1,2-Benzisoxazol-3-ylacetyl chloride 84637-43-4 (CAS 84637-43-4)
- 2-(3-Phenyl-2,1-benzisoxazol-5-yl)-2H-tetrazole-5-carboxylic Acid (CAS 951896-38-1)
Recommended Standards
- 5-Methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (CAS 4926-18-5)
- 5-Methyl-1,2-dihydropyrimido[5,4-e][1,2,4]triazine (CAS 25624-79-7)
- 5-Methyl-[1,2,4]triazolo[1,5-a]pyridin-7-ol (CAS 4461-62-5)
- 5-Methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (CAS 77712-95-9)
- Tert-butyl 4-((S)-1-amino-2-methoxy-2-oxoethyl)-2-methylpiperidine-1-carboxylate (CAS 2387585-39-7)
- 2-Chlorophenyl ethenesulfonate (CAS 1562-33-0)
- Methyl 3-(methylamino)benzoate (CAS 104542-38-3)
- N-methyl-4-thiocyanatoaniline (CAS 33192-08-4)
- H-p-Fluoro-Phe-OH (CAS 1132-68-9)
- 2-Fluoroquinoline-3-carbaldehyde (CAS 224769-43-1)
- Sodium2-(5-sulfido-1H-tetrazol-1-yl)acetate (CAS 61336-49-0)
- Carbaryl Impurity 11 (CAS 32263-67-5)
- 2-Ethynyl-3-fluorobenzaldehyde (CAS 1638606-25-3)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
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