4-(Difluoromethyl)anisole CAS 658-17-3
| CAS No. | 658-17-3 |
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(Difluoromethyl)anisole (CAS 658-17-3) is a high-purity analytical reference standard with the molecular formula C8H8F2O and a molecular weight of 158.15 g/mol.
The molecular framework of 4-(Difluoromethyl)anisole (C8H8F2O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 4-(Difluoromethyl)anisole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
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- (5-(Difluoromethyl)pyridin-3-yl)methanamine (CAS 1256786-89-6)
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Recommended Standards
- 4-(Difluoromethyl)-1-ethynyl-2-oxabicyclo[2.1.1]hexane (CAS 2649757-07-1)
- 4,4-Difluoro-2,6-Dimethyl-2,5-Cyclohexadien-1-One (CAS 318949-59-6)
- 4-(Aminomethyl)-2,5-difluoroaniline (CAS 401909-15-7)
- 4,4-Dimethyl-2-oxotetrahydrofuran-3-carboxylic acid (CAS 412034-82-3)
- cis-(1s,4s)-4-(tert-Butyl)cyclohexan-1-amine (CAS 2163-33-9)
- Ravenine (CAS 20105-22-0)
- 3-(4-Fluorophenyl)-1-(2-nitrophenyl)piperazine (CAS 1148027-25-1)
- 3-fluoro-5-(pyrrolidin-3-yl)pyridine dihydrochloride (CAS 1909308-50-4)
- Methyl 2-amino-2-methyl-5-(4-methyl-1h-pyrazol-1-yl)pentanoate (CAS 1248432-55-4)
- 4-Bromobenzene-1,2,3-triol (CAS 17345-72-1)
- 2-[1-(4-chlorophenyl)ethylidene]malononitrile (CAS 3111-60-2)
- 3,5-Dimethyl-4-(trifluoromethyl)-1h-pyrazole (CAS 1365265-17-3)
- 1-Nitropyrazole (CAS 7119-95-1)
- ((Cys31,Nva34)-Neuropeptide Y (27-36))2 (CAS 172997-92-1)
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