1-(Difluoromethoxy)-4-methoxybenzene CAS 659-33-6
| CAS No. | 659-33-6 |
| Molecular Formula | C8H8F2O2 |
| Molecular Weight | 174.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 1-(Difluoromethoxy)-4-methoxybenzene (C8H8F2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 174.14 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-(Difluoromethoxy)-4-methoxybenzene (CAS 659-33-6) is a high-purity analytical reference standard with the molecular formula C8H8F2O2 and a molecular weight of 174.14 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 1-(Difluoromethoxy)-4-methoxybenzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8F2O2 |
| Molecular Weight | 174.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- (3-(Difluoromethoxy)phenyl)methanol (CAS 125903-81-3)
- 2-(Difluoromethoxy)-5-methylphenol (CAS 1261794-30-2)
- (4-(Difluoromethoxy)phenyl)methanol (CAS 170924-50-2)
- [2-(Difluoromethoxy)phenyl]methanol (CAS 72768-94-6)
- 1-(Difluoromethoxy)-2-methoxybenzene (CAS 97963-81-0)
- (6-(Difluoromethoxy)pyridin-3-yl)methanamine (CAS 1198103-43-3)
- [5-(difluoromethoxy)pyridin-2-yl]methanamine (CAS 1206978-02-0)
- 6-(Difluoromethoxy)-4-methylpyridin-3-amine (CAS 1268390-63-1)
Recommended Standards
- 1,2-Difluoro-3-(methoxymethoxy)benzene (CAS 749230-18-0)
- 1,2-Difluoro-4,5-dimethoxybenzene (CAS 203059-80-7)
- (4,5-Difluoro-2-methoxyphenyl)methanol (CAS 886761-72-4)
- 1,2-DIfluoro-4-methoxymethoxy-benzene (CAS 749230-22-6)
- tert-butyl trans-2,3-dimethylpiperazine-1-carboxylate (CAS 2702250-54-0)
- Tert-butyl 4-cyano-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate (CAS 634465-43-3)
- 4-{2-[2-(sec-Butyl)phenoxy]ethyl}piperidinehydrochloride (CAS 1219949-26-4)
- 0154AF 3-(5-Fluoro-1H-benzoimidazol-2-yl)-propionic acid 82138-57-6 C10H9FN2O2 (CAS 82138-57-6)
- (2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-2-yl)methanol (CAS 153332-63-9)
- 2-(1H-imidazol-2-yl)-2-phenylethan-1-amine dihydrochloride (CAS 1803605-54-0)
- HTMU (CAS 1240264-01-0)
- 2-Bromo-3-(difluoromethyl)-5-iodo-4-nitropyridine (CAS 1806870-85-8)
- n-(Cyclopropylmethyl)-1-(thiazol-2-yl)ethan-1-amine (CAS 937667-32-8)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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