1-[3-(trifluoromethyl)phenyl]-1h-pyrazol-3-amine CAS 66000-41-7
| CAS No. | 66000-41-7 |
| Molecular Formula | C10H8F3N3 |
| Molecular Weight | 227.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-[3-(trifluoromethyl)phenyl]-1h-pyrazol-3-amine (C10H8F3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
1-[3-(trifluoromethyl)phenyl]-1h-pyrazol-3-amine (CAS 66000-41-7), molecular formula C10H8F3N3 and molecular weight 227.19 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-[3-(trifluoromethyl)phenyl]-1h-pyrazol-3-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8F3N3 |
| Molecular Weight | 227.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related trifluoromethyl Standards
- 7-(Trifluoromethyl)quinoline-3,4-diamine (CAS 110643-85-1)
- 1-(3-(Trifluoromethyl)benzyl)-1H-1,2,4-triazole (CAS 115201-44-0)
- 3-[5-(trifluoromethyl)-1h-pyrazol-1-yl]aniline (CAS 1152530-85-2)
- 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-amine (CAS 1153040-21-1)
- 1-(2-(Trifluoromethyl)phenyl)-1h-pyrazol-3-amine (CAS 1248322-84-0)
- 1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-amine (CAS 1251264-73-9)
- 3-[4-(trifluoromethyl)-1h-pyrazol-1-yl]aniline (CAS 1306605-68-4)
- 1-(2-(Trifluoromethyl)phenyl)-1h-pyrazol-5-amine (CAS 1349717-35-6)
Recommended Standards
- 1-(4-(Trifluoromethyl)phenyl)-1h-pyrazol-5-amine (CAS 76606-49-0)
- 2-(1h-Imidazol-1-yl)-5-(trifluoromethyl)aniline (CAS 380389-67-3)
- 1-(3-(Trifluoromethyl)phenyl)-1h-pyrazol-5-amine (CAS 78119-07-0)
- 2-(1h-Pyrazol-1-yl)-5-(trifluoromethyl)aniline (CAS 883881-78-5)
- Ethyl 7-(3-chlorothiophen-2-yl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxylate (CAS 477859-11-3)
- 1-(3-Nitrobenzoyl)piperidine-4-carboxylic acid (CAS 352673-01-9)
- rac-trans 3’-Hydroxymethylnicotine Hemisuccinate (CAS 1207282-59-4)
- Ethyl 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine-2-carboxylate (CAS 623565-57-1)
- 3-Amino-5-bromo-7-iodo-1H-indazole (CAS 1935186-93-8)
- Quinolin-8-yl furan-2-carboxylate (CAS 18060-51-0)
- m-PEG5-phosphonic acid ethyl ester (CAS 1807512-42-0)
- 1-(3-(2,6-Dichlorophenyl)-1,2,4-oxadiazol-5-yl)-N,N-dimethylmethanamine (CAS 680216-25-5)
- Rutaretin (CAS 13895-92-6)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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