1-(4-Fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid CAS 66183-72-0
| CAS No. | 66183-72-0 |
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1-(4-Fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid (CAS 66183-72-0), a certified reference material (molecular formula C12H12FNO3, MW 237.23 g/mol) for analytical method development and quality control.
The molecular framework of 1-(4-Fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid (C12H12FNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(4-Fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorobenzyl Standards
- 1-(3-Fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid (CAS 116344-62-8)
- 1-(2-Fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 845546-24-9)
- 1-(3-Fluorobenzyl)-5-oxo-pyrrolidine-3-carboxylic acid (CAS 845546-23-8)
- 6-(4-Fluorobenzyl)-3-mercapto-1,2,4-triazin-5-ol (CAS 104517-60-4)
- 2-Fluorobenzyl 4-amino-1,2,5-oxadiazole-3-carboxylate (CAS 340828-48-0)
- 1-(4-Fluorobenzyl)piperidine-2-carboxylic acid (CAS 1030610-75-3)
- 1-(2-Fluorobenzyl)piperidine-2-carboxylic acid (CAS 1038577-25-1)
- 4-Fluorobenzyl piperidine-4-carboxylate (CAS 1267245-27-1)
Recommended Standards
- 1-(4-Fluorobenzoyl)proline (CAS 2098813-19-3)
- 1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carbohydrazide (CAS 669696-68-8)
- 1-(4-Fluoro-3-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 63675-02-5)
- 1-(5-amino-2-fluoro-4-methyl-phenyl)hexahydropyrimidine-2,4-dione (CAS 2703773-53-7)
- 1-(2,4-Difluorophenyl)-2-(ethylthio)ethan-1-one (CAS 229153-21-3)
- 2-Pyrrolidin-1-yl-ethanol (CAS 30727-31-2)
- 2-Ethynylbenzamide (CAS 1207252-50-3)
- 6-Bromo-2,4-dimethylpyridin-3-amine hydrobromide (CAS 2140305-91-3)
- 2-{1-methyl-4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}acetic acid (CAS 923138-37-8)
- 3-(1H-Pyrazol-5-yl)piperidine (CAS 774479-26-4)
- Trimethyl(2-(phenylsulfonyl)ethyl)silane (CAS 73476-18-3)
- 3-Bromo-2,4-dimethylaniline (CAS 66314-77-0)
- Thiamine (CAS 70-16-6)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com