3-chloro-5-[4-({[3-(trifluoromethyl)phenyl]thio}methyl)phenyl]isothiazole-4-carbonitrile CAS 662138-28-5
| CAS No. | 662138-28-5 |
| Molecular Formula | C18H10ClF3N2S2 |
| Molecular Weight | 410.86 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-chloro-5-[4-({[3-(trifluoromethyl)phenyl]thio}methyl)phenyl]isothiazole-4-carbonitrile (CAS 662138-28-5) is a high-purity analytical reference standard with the molecular formula C18H10ClF3N2S2 and a molecular weight of 410.86 g/mol.
3-chloro-5-[4-({[3-(trifluoromethyl)phenyl]thio}methyl)phenyl]isothiazole-4-carbonitrile (C18H10ClF3N2S2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 3-chloro-5-[4-({[3-(trifluoromethyl)phenyl]thio}methyl)phenyl]isothiazole-4-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H10ClF3N2S2 |
| Molecular Weight | 410.86 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related chloro Standards
- 2-Chloro-N-(3-cyano-4-(o-tolylsulfonyl)phenyl)benzamide (CAS 320421-32-7)
- 4-Chloro-N-(3-cyano-4-tosylphenyl)benzamide (CAS 320421-31-6)
- 6-Chloro-4-methanesulfonyl-N-[(3-methoxyphenyl)methyl]-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide (CAS 866142-58-7)
- 6-Chloro-N-(2-methoxybenzyl)-4-(methylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide (CAS 866142-56-5)
- N-(5-Chloro-3-(phenylsulfonyl)-1H-indol-2-yl)benzamide (CAS 918493-52-4)
- 3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-(2-fluorobenzyl)-1H-pyrazole (CAS 956783-86-1)
- 4-Chloro-N-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)benzamide (CAS 866018-71-5)
- Ethyl 6-chloro-2-(morpholinomethyl)-4-phenylquinoline-3-carboxylate (CAS 126334-93-8)
Recommended Standards
- 2,4,6-Tribromophenyl SulfateDiscontinued see T772648 (CAS 1408251-85-3)
- (2Z)-2-(4-chlorobenzenesulfonyl)-3-[(4-phenoxyphenyl)amino]prop-2-enenitrile 1024714-08-6 MS-11306 (CAS 1024714-08-6)
- fluoro-Dapagliflozin (CAS 1181681-43-5)
- 6-(5-(4-Aminobutyl)-3-chloro-2-fluorophenyl)-3-phenyl-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one (CAS 1393887-94-9)
- 2-Chloro-4-acetamido-6-amino-s-triazine (CAS 115339-34-9)
- tert-Butyl 2-(((4-chloro-5-methylpyrimidin-2-yl)oxy)methyl)pyrrolidine-1-carboxylate (CAS 1289385-82-5)
- 3-amino-N-[(2-bromophenyl)methyl]-N-methylpropanamide (CAS 1183588-80-8)
- Sodium 4-chloro-2,5-difluorobenzoate (CAS 1421029-91-5)
- 4-Chloro-3,5-bis(3,4-dimethoxyphenyl)-1h-pyrazole (CAS 1159988-73-4)
- (S)-4-Bromo-N-(1-hydroxypropan-2-yl)-3-methylbenzamide (CAS 1568249-13-7)
- 2-(3-Amino-5,6-dihydrocyclopenta[c]pyrazol-2(4h)-yl)acetic acid (CAS 1493259-67-8)
- 4-(3-Methoxybenzoyl)quinoline (CAS 1706450-30-7)
- (2-((Pyrrolidin-1-ylsulfonyl)methyl)phenyl)methanamine (CAS 1041567-12-7)
- Semaglutide Impurity 6 (CAS 62-57-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com