5-((4-Chlorophenyl)amino)-6-hydroxy-2-(methylthio)pyrimidin-4(3H)-one CAS 6630-69-9
| CAS No. | 6630-69-9 |
| Molecular Formula | C21H21ClN5O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-((4-Chlorophenyl)amino)-6-hydroxy-2-(methylthio)pyrimidin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-((4-Chlorophenyl)amino)-6-hydroxy-2-(methylthio)pyrimidin-4(3H)-one (CAS 6630-69-9), molecular formula C21H21ClN5O2C2H3O2 and molecular weight 469.93 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-((4-Chlorophenyl)amino)-6-hydroxy-2-(methylthio)pyrimidin-4(3H)-one (C21H21ClN5O2C2H3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C21H21ClN5O2 C2H3O2 |
| Molecular Weight | 469.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Chlorophenyl Standards
- 2-(2-Chlorophenyl)-2-(pyrrolidin-1-yl)acetamide (CAS 1000340-02-2)
- N-(2-Chlorophenyl)-5-methyl-1-phenyl-1H-1,2,4-triazole-3-carboxamide (CAS 1000572-01-9)
- N-(2-Chlorophenyl)-5-oxo-1-(p-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000573-94-3)
- Methyl 1-(2-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate (CAS 1000576-85-1)
- 1-(4-Chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylic acid phenylamide (CAS 1000577-01-4)
- Benzyl 1-(4-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate (CAS 1000577-09-2)
- 1-(2-Chlorophenyl)-5-oxo-N-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000577-29-6)
- 2-(2-Chlorophenyl)-1-phenylethan-1-amine (CAS 1000615-44-0)
Recommended Standards
- N-((1-(Thiophen-2-yl)cyclopropyl)methyl)-4-(trifluoromethyl)benzamide (CAS 1207059-14-0)
- TCS 1102 (CAS 916141-36-1)
- 2-Methyl-3-phenylpentanoic acid (CAS 1616-69-9)
- 3-(Benzyl-phenyl-sulfamoyl)-4-chloro-benzoic acid (CAS 733762-51-1)
- Epalrestat Impurity 24 (CAS CATO-C4X-223624)
- 1-(1-Methylpiperidin-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1708268-36-3)
- Ethyl 2-((4-(4-(2-chloroethyl)phenyl)-5-methylthiazol-2-yl)amino)-2-oxoacetate (CAS 866151-07-7)
- Diethylene Glycol-Monoethyl ether (CAS 111-90-0)
- 4-Amino-7-bromoquinazoline (CAS 1123169-43-6)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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