(Z)-Cefazolin Impurity 44 CAS 66338-95-2

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.66338-95-2
Molecular FormulaC6H8ClNO4
Molecular Weight193.59 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

(Z)-Cefazolin Impurity 44 CAS 66338-95-2 chemical structure

Description

The occurrence of (Z)-Cefazolin Impurity 44 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies (Z)-Cefazolin Impurity 44 (CAS 66338-95-2), a pharmacopoeial impurity reference standard (molecular formula C6H8ClNO4, MW 193.59 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of (Z)-Cefazolin Impurity 44 (C6H8ClNO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), (Z)-Cefazolin Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC6H8ClNO4
Molecular Weight193.59 g/mol
AppearanceWhite to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity>90%
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1975
Halogen ContentCl-containing
Nitrogen Atoms1

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