Glipizide EP Impurity E CAS 66375-96-0
| CAS No. | 66375-96-0 |
| Molecular Formula | C21H27N5O4S |
| Molecular Weight | 445.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Glipizide EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Glipizide EP Impurity E (CAS 66375-96-0) is a certified pharmaceutical impurity reference standard with the molecular formula C21H27N5O4S and a molecular weight of 445.54 g/mol.
Structurally, Glipizide EP Impurity E (C21H27N5O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 445.54 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H27N5O4S |
| Molecular Weight | 445.54 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Glipizide Standards
- Glipizide Impurity 33 (CAS CATO-C4X-140733)
- Glipizide (CAS 29094-61-9)
- Glipizide Impurity 34 (CAS 14511-59-2)
- Glipizide EP Impurity I (CAS 10079-35-3)
- Glipizide Impurity 39 (CAS CATO-C4X-140739)
- Glipizide Impurity 25 (CAS CATO-C4X-140725)
- Glipizide Impurity 49 (CAS CATO-C4X-140749)
- Glipizide Impurity 50 (CAS CATO-C4X-140750)
Recommended Standards
- Cefmetazole Impurity 37 (CAS CATO-C4X-150737)
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- 1-(4-Hydroxy-3,5-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol (CAS 92409-34-2)
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- tert-Butyl 2-(4-(aminomethyl)phenoxy)acetate (CAS 720720-14-9)
- cis-5-cis-13-Docosadienoic Acid (CAS 676-39-1)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
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