7-Methoxy-2,2-dimethyl-2H-chromen-5-amine hydrochloride CAS 66385-03-3
| CAS No. | 66385-03-3 |
| Molecular Formula | C12H15NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Methoxy-2,2-dimethyl-2H-chromen-5-amine hydrochloride (CAS 66385-03-3) is a high-purity analytical reference standard with the molecular formula C12H15NO2HCl and a molecular weight of 241.72 g/mol.
The molecular framework of 7-Methoxy-2,2-dimethyl-2H-chromen-5-amine hydrochloride (C12H15NO2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H15NO2 HCl |
| Molecular Weight | 241.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- Methyl 2-Chloroquinazoline-5-carboxylate (CAS 1221288-22-7)
- (5-(1H-1,2,4-Triazol-3-yl)tetrahydrofuran-2-yl)methanamine (CAS 1526342-93-7)
- 4-Bromoquinoline-6-carboxylic acid (CAS 219763-87-8)
- Tert-butyl 3,3-difluoro-4-(4-nitrophenoxy)piperidine-1-carboxylate (CAS 2101206-39-5)
- 2-Bromo-1-(3,4,5-trifluorophenyl)ethan-1-one (CAS 443914-94-1)
- 2,5-dichloro-1H-pyrimidin-6-one;sodium salt (CAS 2438558-72-4)
- 2-Methylpyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidin-4(6H)-one (CAS 1160261-62-0)
- 3-{4-[(3,5-dichlorophenyl)sulfonyl]piperazino}-6-phenylpyridazine 478077-50-8 KS-00003DJ6 (CAS 478077-50-8)
- 1-((2,5-Difluorophenyl)thio)propan-2-one (CAS 1152967-45-7)
- Biotinyl-Neuropeptide W-23 (human) (CAS 1815618-09-7)
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